AA29504
AA29504 is a ethyl carbamate with γ-aminobutyric acid (GABAA(HY-L120) receptor activity. AA29504 inhibits the delivery of the neurotransmitter gamma-aminobutyric acid in the central nervous system. AA29504 can be used to research anxiety, insomnia and other neuropsychiatric diseases .
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- No. CAS: 945828-50-2
- Fòrmula: C19H25N3O2
- Peso molecular:327.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
AA29504 (0.1, 1, 10, 100 μM, 72 h) can open the Kv7 voltage-gated K+ channels (KCNQ) in Xenopus oocytes [1].
AA29504 (1 μM) positively regulates GABAA receptors expressed in Xenopus oocytes, EC501.4 μM[1] .
AA29504 (1 μM, 10 s) significantly enhances the gaboxadol-mediated current in pyramidal neurons of the prefrontal cortex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AA29504 (4 mg/kg, subcutaneous injection) significantly weakenes the motor coordination of male SD rats under the synergistic effect of alcohol [1].
AA29504 (2.5, 5 and 10 mg/kg, subcutaneously injection) has therapeutic effect on amygdala ignited seizures in male Wistar rats [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Spraguee Dawley rats [1]
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Dosage:0.5, 2 or 4 mg/kg
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Administration:Subcutaneous injections
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Result:Reduced the number of vocalizations at 4 mg/kg and reversed partially the freezing behavior at 2 mg/kg.
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Animal Model:Male Spraguee Dawley rats [1]
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Dosage:4 mg/kg
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Administration:Subcutaneous injections
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Result:Reduced the time the rats stayed on the rotarod at 4 mg/kg.
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Animal Model:Male Wistar rats [1]
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Dosage:10 mg/kg
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Administration:Subcutaneous injections
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Result:Reduced from 4.9 to 2.0 in amygdala kindled seizures response.
Chemical Information
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No. CAS 945828-50-2
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Peso molecular 327.42
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Fòrmula C19H25N3O2
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SMILES
O=C(NC1=CC=C(NCC2=C(C)C=C(C)C=C2C)C=C1N)OCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AA29504 Related Classifications
HY-103522 Related Classifications
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