AAA-10 formic
Based on 1 publication(s) in Google Scholar
AAA-10 formic is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C26H43FO7S
- Peso molecular:518.68
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) AAA-10 formic
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Actividad biológica
IC50: 10 nM (B. theta rBSH), 80 nM (B. longum rBSH)[1]
AAA-10 (100 μM; 24 h) formic inhibits BSH activity in bacterial cultures, with IC50s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively[1].
AAA-10 (20 μM; 2 h) formic significantly inhibits deconjugation of glycochenodeoxycholic acid-d4 or taurocholic acid-d4 substrates of human feces[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AAA-10 (30 mg/kg) formic displays high colonic exposure and low gut permeability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:10-11 weeks old male C57Bl/6J mice[1]
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Dosage:30 mg/kg
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Administration:Orally gavaged once daily for 5 days
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Result:Decreased the abundances of DCA and LCA in mice feces starting in day 2-5.
Displayed high colonic exposure and low gut permeability.
Chemical Information
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Peso molecular 518.68
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Fòrmula C26H43FO7S
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SMILES
C[C@H](CCC(CF)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](OS(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.O=CO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea. [Abstract]2024 Aug 21:S1931-3128(24)00290-7. PMID: 39214086
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AAA-10 formic Related Classifications
HY-145147A Related Classifications
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