AChE-IN-14
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease.
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- No. CAS: 2390042-05-2
- Fòrmula: C28H35NO3
- Peso molecular:433.58
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
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AChE |
In Vitro
AChE-IN-14 (compound 5) has a good affinity to human H3 receptor with a Ki value of 159.8 nM in HEK293 cells[1].
AChE-IN-14 has a high orally activity and cannot cross the blood-brain barrier[1].
AChE-IN-14 (10 μM, 5 min) inhibits hAChE with an IC50 value of 0.48 μM and represents the non-competitive type of eeAChE (Ki = 176 nM) and eqBuChE (Ki = 281 nM) inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2390042-05-2
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Peso molecular 433.58
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Fòrmula C28H35NO3
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SMILES
O=C1C=C(C2=CC=C(OCCCCCCN3CCCCCC3)C=C2)OC4=CC=C(C)C=C14
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-14 Related Classifications
HY-146035 Related Classifications
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