Angustone B
Angustone B is a pyranoisoflavone compound and an antifeedant. Angustone B can be isolated from the roots of Lupinus albus and Lupinus angustifolius. Angustone B exhibits feeding inhibitory activity against larvae of Costelytra zealandica.
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- No. CAS: 100462-54-2
- Fòrmula: C25H24O6
- Peso molecular:420.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
7.07 μM
Compound: 34
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
|
[PMID: 28522265] |
| MCF7 | IC50 |
8.58 μM
Compound: 34
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay
|
[PMID: 28522265] |
| SW480 | IC50 |
6.72 μM
Compound: 34
|
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay
|
[PMID: 28522265] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Third-instar larvae (field-collected)[2]
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Dosage:200 μg/g
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Administration:incorporated into feeding disks; single exposure
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Result:Reduced larval feeding to 74% of the standard stimulated response based on Hodges-Lehmann estimates.
Showed no significant dose-response correlation across the tested concentration range.
Noted a significant reduction in feeding at an unspecified lower concentration.
Chemical Information
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No. CAS 100462-54-2
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Peso molecular 420.46
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Fòrmula C25H24O6
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SMILES
O=C1C(=COC2=CC(O)=C(C(O)=C12)CC=C(C)C)C=3C=CC=4OC(C=CC4C3O)(C)C
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)