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Referencia número: HY-178777

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BCL6-760

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC₅₀ of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker).
(Pink: BCL6 ligand (HY-179317); Blue: no E3 ligase ligand; Black: linker).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3084696-50-1
Fòrmula: C₃₆H₄₃ClN₁₀O₄
Peso molecular:715.24

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BCL6-760 Chemical Structure

No. CAS: 3084696-50-1

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Actividad biológica
- Descripciòn
- In Vitro
- Parmacokinetics
- In Vivo
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Actividad biológica

Descripciòn

BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC₅₀ of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker)^[1]. (Pink: BCL6 ligand (HY-179317); Blue: no E3 ligase ligand; Black: linker).

Ver todos los productos específicos de isoformas PROTACs :

In Vitro

BCL6-760 inhibits OCI-LY-1 cells growth with a GI₅₀ of 1.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-24	F	CL	V_ss	MRT
Mice^[1]	10 mg/kg	p.o.	4.86 μM	1.3 h	15.8 μM·h	22 %	/	/	/
Mice^[1]	2 mg/kg	i.v.	/	/	14.7 μM·h	/	3.53 mL/min/kg	0.25 L/kg	1.2 h

In Vivo

BCL6-760 (15-60 mg/kg, p.o., once or twice daily for 5 days) effectively and continuously degrades the BCL6 protein in tumors, and produces significant anti-tumor effects in OCI-LY-1 tumor xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3084696-50-1
Peso molecular 715.24
Fòrmula C₃₆H₄₃ClN₁₀O₄
SMILES

CN(C1=NC(NC2=CC=C3N(C(N(C3=C2)CCC(C)(O)C)=O)C)=C(C=N1)Cl)C4CCN(C5=CC6=C(C(C7CCC(NC7=O)=O)=NN6C)C=C5)CC4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Shunatona HP, et al. Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760. J Med Chem. 2025 Oct 23;68(20):21502-21519. [Content Brief]

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BCL6-760

Ver todos los productos específicos de isoformas PROTACs

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

BCL6-760 Related Classifications

HY-178777 Related Classifications