Cusculine
Based on 1 Customer Validation
Cusculine (FAC21) is an oropouche virus (OROV) endonuclease inhibitor with an IC50 of 1.4 μM. Cusculine strongly interacts with OROV endonuclease, possibly limiting viral RNA interaction with other proteins, intercalates into double-stranded RNA (a viral replication intermediate), and efficiently inhibits OROV viral replication in vitro. Cusculine can be used for the research of oropouche fever.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.76%
- No. CAS: 143438-95-3
- Fòrmula: C18H19NO6
- Peso molecular:345.35
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
8.5 μg/mL
Compound: 2, Cusculine
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Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
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[PMID: 1431935] |
Cusculine (FAC21) (72 h) exhibits low cytotoxicity in Vero cells (CC50 = 1640 μM)[1].
Cusculine (15.125-250 μM) potently inhibits OROV infection in Vero cells (EC50 = 33.03 μM)[1].
Cusculine (125 μM; 8-48 hpi) strongly inhibits OROV replication early in Vero cells (99.9% inhibition at 8 hpi)[1].
Cusculine (18.5 μM; 45 min) modestly interacts with dsRNA, showing partial intercalation activity[1].
Cusculine (0-90 μM; 10 min) potently inhibits OROV N-terminal endonuclease as a competitive inhibitor (IC50 = 1.4 μM)[1].
Cusculine stably binds to the active site of OROV N-terminal endonuclease, with favorable binding free energy and conserved interacting residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 143438-95-3
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Appearance Solid
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Peso molecular 345.35
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Fòrmula C18H19NO6
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Color Light yellow to yellow
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SMILES
O=C1C2=CC=C(OC)C(OC)=C2NC3=CC(OC)=C(OC)C(OC)=C13
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Synonyms
FAC21
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cusculine Related Classifications
HY-N17251 Related Classifications
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