DBPR116
Based on 1 Customer Validation
DBPR116 is a prodrug of BPRMU191 (HY-159923) with blood-brain barrier penetration capability. DBPR116 significantly improves the delivery of centrally targeted drugs. In combination with the antagonist Naltrexone (HY-76711), DBPR116 demonstrated superior safety and analgesic efficacy compared to morphine in various in vivo pharmacological studies, including thermal pain models, cancer pain models, constipation, sedation, psychological dependence, heart rate, and respiratory frequency. As a prodrug strategy for peripheral administration, DBPR116 effectively alleviates pain while reducing adverse effects, showing potential as a safer opioid analgesic.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.90%
- No. CAS: 2131200-75-2
- Fòrmula: C19H18FNO3S
- Peso molecular:359.41
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 2131200-75-2
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Appearance Solid
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Peso molecular 359.41
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Fòrmula C19H18FNO3S
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Color Colorless to off-white
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SMILES
O=C(C1=CC=C(N2C(CSC2C3=CC=C(C=C3)F)=O)C(C)=C1)OCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (278.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7823 mL | 13.9117 mL | 27.8234 mL | 69.5584 mL |
| 5 mM | 0.5565 mL | 2.7823 mL | 5.5647 mL | 13.9117 mL | |
| 10 mM | 0.2782 mL | 1.3912 mL | 2.7823 mL | 6.9558 mL | |
| 15 mM | 0.1855 mL | 0.9274 mL | 1.8549 mL | 4.6372 mL | |
| 20 mM | 0.1391 mL | 0.6956 mL | 1.3912 mL | 3.4779 mL | |
| 25 mM | 0.1113 mL | 0.5565 mL | 1.1129 mL | 2.7823 mL | |
| 30 mM | 0.0927 mL | 0.4637 mL | 0.9274 mL | 2.3186 mL | |
| 40 mM | 0.0696 mL | 0.3478 mL | 0.6956 mL | 1.7390 mL | |
| 50 mM | 0.0556 mL | 0.2782 mL | 0.5565 mL | 1.3912 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4637 mL | 1.1593 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3478 mL | 0.8695 mL | |
| 100 mM | 0.0278 mL | 0.1391 mL | 0.2782 mL | 0.6956 mL |
DBPR116 Related Classifications
HY-159924 Related Classifications
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