Denopterin
Denopterin is a dihydrofolate reductase (DHFR) inhibitor and an antifolate agent. Denopterin is an antimetabolite that has toxic effects on cells and can be used for cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 22006-84-4
- Fòrmula: C21H23N7O6
- Peso molecular:469.45
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
VHL |
Antibody-drug conjugates (ADCs) have great promise as anti-cancer drugs. In recent years, there has been increasing applications of the pyrrolobenzo-diazepine dimer (PBD) class of cytotoxic payloads as ADC therapeutics due to PBDs’extream potency against most of the US National Cancer Institute’s (NCI’s) NCI 60-tumor-cell line panels along with unique mechanism of antitumor antibiotics activity. All PBDs are usually conjugated to an antibody with one conditionally stable linker, because it is normally believed that linkers of ADCs must be stable while the ADC is circulating in the blood to limit off-target toxicity, but allow for release of the drug once it is inside the target cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 22006-84-4
-
Peso molecular 469.45
-
Fòrmula C21H23N7O6
-
SMILES
O=C1C2=NC(C(C)N(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C)=CNC2=NC(N)=N1
-
Synonyms
Pteroylglutamic acid
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Denopterin Related Classifications
HY-121207 Related Classifications
Powered by Bioz