Eras-4001-d6
Eras-4001-d6 is a deuterated form of Eras-4001 (HY-175870). Eras-4001 is a potent, orally active pan-KRAS inhibitor with Kd values of 110, 13 and 39 pM against wild-type, G12D and G12V mutant KRAS, respectively, and exhibits selectivity toward wild-type HRAS and NRAS. Eras-4001 inhibits ERK1/2 phosphorylation and cell viability in cancer cells. Eras-4001 induces tumor growth inhibition and regression in subcutaneous xenograft models. Eras-4001 can be used in research on non-small cell lung cancer, ovarian cancer, etc.
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- No. CAS: 3024881-00-0
- Fòrmula: C36H33D6ClF4N8O3
- Peso molecular:749.24
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
K-Ras WT 110 pM (Kd) |
KRas G12D 13 pM (Kd) |
KRas G12V 39 pM (Kd) |
N-Ras 2460 nM (Kd) |
H-Ras 196 nM (Kd) |
ERK1 |
ERK2 |
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 3024881-00-0
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Peso molecular 749.24
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Fòrmula C36H33D6ClF4N8O3
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SMILES
C(OC1=NC(=C2C(=N1)C[C@H](OC2)C3=C(C(F)(F)F)C(C#CC)=CC(N)=C3F)N4CC=5N(CCC4)N=C(C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C5Cl)[C@@]67N(CC(=C)C6)CCC7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eras-4001-d6 Related Classifications
HY-175870S Related Classifications
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