MST1 - macrophage stimulating 1 Gene

Also Known as MSP; HGFL; NF15S2; D3F15S2; DNF15S2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4485

About MST1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,683,947-49,689,474 (from NCBI)

This gene has 21 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 45.2), duodenum (RPKM 24.6) and 13 other tissues.

Summary

The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]

MST1 Products (6)

mRNA Protein Name
NM_001393581.1 NP_001380510.1 hepatocyte growth factor-like protein isoform 2 precursor
NM_001393582.1 NP_001380511.1 hepatocyte growth factor-like protein isoform 3 precursor
NM_001393583.1 NP_001380512.1 hepatocyte growth factor-like protein isoform 4 precursor
NM_001393584.1 NP_001380513.1 hepatocyte growth factor-like protein isoform 5 precursor
NM_001393585.1 NP_001380514.1 hepatocyte growth factor-like protein isoform 6 precursor
NM_020998.4 NP_066278.3 hepatocyte growth factor-like protein isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
22087277 GOA
enables receptor tyrosine kinase binding IDA
IDA: Inferred from direct assay
22087277 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in negative regulation of gluconeogenesis IDA
IDA: Inferred from direct assay
19720831 GOA
involved in regulation of cAMP-dependent protein kinase activity IDA
IDA: Inferred from direct assay
19720831 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in extracellular space IDA
IDA: Inferred from direct assay
7508914 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte growth factor-like protein

  • hepatocyte growth factor-like protein homolog

MST1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
MST1 P26927 MST1R Homo sapiens Q04912
X-Ray Diffraction
25193665
Intra
MST1 P26927 SFT2D1 Homo sapiens Q8WV19
Validated Y2H
32296183
Intra
MST1 P26927 SFT2D1 Homo sapiens Q8WV19
Y2H Prey Pooling
32296183
Intra
MST1 P26927 SFT2D1 Homo sapiens Q8WV19
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

MST1 Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P810549 Phospho-MST1/MST2 (Thr180 + Thr183) Antibody (YA9818) WB Human, Mouse, Rat
HY-P81903 MSP Antibody (YA1648) WB, ICC/IF, IP Human, Mouse, Rat
HY-P81903A MSP Antibody (YA1648)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat
HY-P82623 MST1 Antibody (YA2368) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Cholangitis, Primary Sclerosing

  • Primary Sclerosing Cholangitis

  • PSC

  • Sclerosing Cholangitis

  • Cholangitis, Sclerosing

  • Cholangitis Primary Sclerosing

  • Psc - [Primary Sclerosing Cholangitis]
Inflammatory Bowel Disease 12

  • IBD12
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-132969 SBP-3264 Inhibitor 98.50% Unkown
HY-164595 IHMT-MST1-39 Inhibitor 99.68% Unkown
HY-186148 YL-602 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MST1 VGNC VGNC:81281
Felis catus MST1 VGNC VGNC:80630
Mus musculus MST1 MGD MGI:96080
Rattus norvegicus MST1 RGD RGD:3114
Others MST1 NCBI