NOVA2 - NOVA alternative splicing regulator 2 Gene

Also Known as ANOVA; NOVA3; NEDASB; NOVA-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4858

About NOVA2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,933,734-45,973,865 (from NCBI)

This gene has 4 transcripts (splice variants), 119 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 7.5), fat (RPKM 2.1) and 10 other tissues.

Summary

Enables sequence-specific mRNA binding activity. Involved in neuron differentiation and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NOVA2 Products (1)

mRNA Protein Name
NM_002516.4 NP_002507.1 RNA-binding protein Nova-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
enables RNA binding IDA
IDA: Inferred from direct assay
32197073 GOA
enables sequence-specific mRNA binding IDA
IDA: Inferred from direct assay
10811881 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
32197073 GOA
involved in regulation of RNA metabolic process IMP
IMP: Inferred from mutant phenotype
32197073 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
32197073 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOVA2 Protein Structure

KH_1

KH_1: KH domain (36 - 94)

KH_1

KH_1: KH domain (133 - 196)

KH_1

KH_1: KH domain (410 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
Protein Preferred Names Protein Names

RNA-binding protein Nova-2

  • astrocytic NOVA1-like RNA-binding protein

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Or Without Autistic Features And/Or Structural Brain Abnormalities

  • NEDASB

  • Neurodevelopmental Disorder With/Without Autistic Features And/Or Structural Brain Abnormalities
Paraneoplastic Polyneuropathy
Fragile X Syndrome

  • FXS

  • Martin-Bell Syndrome

  • Fraxa Syndrome

  • Marker X Syndrome

  • X-Linked Mental Retardation And Macroorchidism

  • Fragile X Mental Retardation Syndrome

  • Fra Syndrome

  • Mental Retardation, X-Linked, Associated With Marxq28

  • X-Linked Intellectual Disability And Macroorchidism

  • Frax Syndrome

  • Symptomatic Form Of Fragile X Syndrome In Female Carriers

  • Fragile-X Syndrome

  • Fraxe Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS09456 NOVA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NOVA2 MGD MGI:104296
Canis familiaris NOVA2 VGNC VGNC:53745
Bos taurus NOVA2 VGNC VGNC:32181
Felis catus NOVA2 VGNC VGNC:97531
Rattus norvegicus NOVA2 RGD RGD:1308032
Others NOVA2 NCBI