RORB - RAR related orphan receptor B Gene

Also Known as RZRB; EIG15; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6096

About RORB

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:74,497,335-74,693,177 (from NCBI)

This gene has 2 transcripts (splice variants), 398 orthologues, 18 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 5.4), endometrium (RPKM 3.4) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

RORB Products (2)

mRNA	Protein	Name
NM_006914.4	NP_008845.2	nuclear receptor ROR-beta isoform 1
NM_001365023.1	NP_001351952.1	nuclear receptor ROR-beta isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23555304	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	27352968	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RORB Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
470 a.a.

Protein Preferred Names	Protein Names
nuclear receptor ROR-beta	RAR-related orphan receptor beta nuclear receptor RZR-beta nuclear receptor subfamily 1 group F member 2 retinoic acid-binding receptor beta retinoid-related orphan receptor beta

RORB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Cross	RORB	Q92753	Clock	Mus musculus	O08785	Anti Tag CoIP	23555304
Cross	RORB	Q92753	Clock	Mus musculus	O08785	Y2H	23555304

Cross: Cross-species interaction Intra: Intraspecies interaction

RORB Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P82662	RORB Antibody (YA2407)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Epilepsy, Idiopathic Generalized	Idiopathic Generalized Epilepsy Generalised Epilepsy Epilepsy, Generalized EIG Ige Epilepsy, Idiopathic Generalized, Susceptibility To, 1 Epilepsy, Idiopathic Generalized 1 Epilepsy, Idiopathic Generalized, Susceptibility To Epilepsy, Idiopathic, Generalized Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Photosensitive Epilepsy	Pse Photogenic Epilepsy Photoparoxysmal Response Reflex Epilepsy, Photosensitive Photoparoxysmal Response 1
Retinal Degeneration	Degeneration Of Retina
Advanced Sleep Phase Syndrome	Fasps Familial Advanced Sleep-Phase Syndrome Advanced Sleep Phase Syndrome, Familial Familial Advanced Sleep Phase Syndrome Sleep Phase Syndrome, Advanced, Familial Advanced Sleep-Phase Syndrome, Familial
Epilepsy, Childhood Absence 1	Epilepsy, Childhood Absence, Susceptibility To, 1 Epilepsy, Childhood Absence, 1 ECA1
Delayed Sleep Phase Disorder	Delayed Sleep Phase Syndrome Delayed Sleep Phase Syndrome, Susceptibility To DSPD Delayed Sleep Phase Disorder, Susceptibility To DSPS Sleep Phase, Delayed, Disorder Sleep Phase Syndrome, Delayed, Susceptibility To
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Epilepsy, Idiopathic Generalized 15	EIG15 Epilepsy, Idiopathic Generalized, Susceptibility To, 15 Idiopathic Generalized Epilepsy 15 {Epilepsy, Idiopathic Generalized, Susceptibility To, 15}
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS12129	RORB Human Pre-designed siRNA Set A		/	Unkown
HY-RS12130	Rorb Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS12131	Rorb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RORB	MGD	MGI:1343464
Canis familiaris	RORB	VGNC	VGNC:45696
Rattus norvegicus	RORB	RGD	RGD:1306778
Bos taurus	RORB	VGNC	VGNC:34089
Macaca mulatta	RORB	VGNC	VGNC:76718
Felis catus	RORB	VGNC	VGNC:64722
Others	RORB	NCBI