KREMEN2 - kringle containing transmembrane protein 2 Gene

Also Known as KRM2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79412

About KREMEN2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,964,275-2,968,380 (from NCBI)

This gene has 6 transcripts (splice variants), 99 orthologues and 1 paralogue. Biased expression in skin (RPKM 2.2), brain (RPKM 0.7) and 7 other tissues.

Summary

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (Wnt)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the Wnt receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

KREMEN2 Products (4)

mRNA	Protein	Name
NM_001253725.2	NP_001240654.1	kremen protein 2 isoform e precursor
NM_001253726.2	NP_001240655.1	kremen protein 2 isoform f precursor
NM_024507.4	NP_078783.1	kremen protein 2 isoform b precursor
NM_172229.3	NP_757384.1	kremen protein 2 isoform d precursor

KREMEN2 Protein Structure

Kringle

WSC

CUB

0
100
200
300
400
462 a.a.

Protein Preferred Names	Protein Names
kremen protein 2	dickkopf receptor 2

Recombinant KREMEN2 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P77976	Kremen-2 Protein, Human (HEK293, His)	Q8NCW0-1 (G26-A364)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Sclerosteosis 2	SOST2 Sclerosteosis, Type 2
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS07429	KREMEN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18439	Kremen2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24921	Kremen2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P992252	Anti-Kremen2 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KREMEN2	MGD	MGI:1920266
Macaca mulatta	KREMEN2	VGNC	VGNC:74081
Felis catus	KREMEN2	VGNC	VGNC:63168
Rattus norvegicus	KREMEN2	RGD	RGD:1310795
Bos taurus	KREMEN2	VGNC	VGNC:58604
Canis familiaris	KREMEN2	VGNC	VGNC:42512
Others	KREMEN2	NCBI