Kremen-2 Protein, Human (HEK293, His)

Kremen-2 protein is a receptor for Dickkopf protein and cooperates with DKK1/2 to inhibit Wnt/β-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Kremen-2 is positioned as a key regulator in the Wnt signaling pathway, regulating cellular responses to developmental cues. Kremen-2 Protein, Human (HEK293, His) is the recombinant human-derived Kremen-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kremen-2 Protein, Human (HEK293, His) is 339 a.a., with molecular weight of 50-60 kDa.

Kremen-2 Protein serves as a receptor for Dickkopf proteins and collaborates with DKK1/2 to inhibit Wnt/beta-catenin signaling by facilitating the endocytosis of Wnt receptors LRP5 and LRP6. This regulatory role in the Wnt signaling pathway positions Kremen-2 as a key modulator of cellular responses to developmental cues. In limb development, Kremen-2 plays a crucial role by attenuating Wnt signaling, contributing to normal limb patterning, and negatively regulating bone formation. Its interaction with ERLEC1 and formation of a ternary complex with DKK1 and LRP6 underscore the intricate molecular mechanisms through which Kremen-2 participates in the fine-tuning of Wnt signaling and developmental processes.

Human

HEK293

C-His

Q8NCW0 (G26-A364)

79412  [NCBI]

50-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.