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SOX14 - SRY-box transcription factor 14 Gene

Also Known as SOX28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8403

About SOX14

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:137,764,315-137,766,334 (from NCBI)

This gene has 1 transcript (splice variant), 246 orthologues and 20 paralogues.

Summary

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with Other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008]

SOX14 Products (1)

mRNA	Protein	Name
NM_004189.4	NP_004180.1	transcription factor SOX-14

SOX14 Protein Structure

HMG_box

SOXp

0
100
200
240 a.a.

Protein Preferred Names	Protein Names
transcription factor SOX-14	HMG box transcription factor SOX-14

SOX14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	SOX14	O95416	NAIF1	Homo sapiens	Q69YI7	Y2H Prey Pooling	25416956
Intra	SOX14	O95416	NAIF1	Homo sapiens	Q69YI7	Validated Y2H	25416956
Intra	SOX14	O95416	UQCRC1	Homo sapiens	P31930	Validated Y2H	32814053
Intra	SOX14	O95416	UQCRC1	Homo sapiens	P31930	Y2H Pooling	32814053
Intra	SOX14	O95416	UQCRC1	Homo sapiens	P31930	Y2H Array	32814053
Intra	SOX14	O95416	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
Intra	SOX14	O95416	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Prey Pooling	32296183
Intra	SOX14	O95416	KRTAP15-1	Homo sapiens	Q3LI76	Validated Y2H	32296183
Intra	SOX14	O95416	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	SOX14	O95416	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	SOX14	O95416	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	SOX14	O95416	NR3C1	Homo sapiens	P04150	Validated Y2H	32814053
Intra	SOX14	O95416	NR3C1	Homo sapiens	P04150	Y2H Array	32814053
Intra	SOX14	O95416	NR3C1	Homo sapiens	P04150	Y2H Pooling	32814053
Intra	SOX14	O95416	ROR2	Homo sapiens	Q01974	Validated Y2H	32296183
Intra	SOX14	O95416	SPMIP9	Homo sapiens	Q96LM6	Y2H Array	32296183
Intra	SOX14	O95416	SPMIP9	Homo sapiens	Q96LM6	Y2H Prey Pooling	32296183
Intra	SOX14	O95416	SPMIP9	Homo sapiens	Q96LM6	Validated Y2H	32296183
Intra	SOX14	O95416	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	SOX14	O95416	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	SOX14	O95416	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	SOX14	O95416	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	SOX14	O95416	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	SOX14	O95416	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053
Intra	SOX14	O95416	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Intra	SOX14	O95416	ATXN3	Homo sapiens	P54252	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Blepharophimosis
Bestiality	Zoophilia
Moebius Syndrome	Mobius Syndrome Moebius Sequence Oromandibular-Limb Hypogenesis Spectrum Congenital Facial Diplegia MBS Moebius Congenital Oculofacial Paralysis Absence Or Underdevelopment Of The 6th And 7th Cranial Nerves Congenital Facial Diplegia Syndrome Congenital Oculofacial Paralysis Congenital Ophthalmoplegia And Facial Paresis Moebius Spectrum Möbius Sequence Möbius Syndrome Mobius Ii Syndrome
Dihydropyrimidinase Deficiency	Dihydropyrimidinuria Dpys Deficiency Dph Deficiency DPYSD Dihydrouracil Amidohydrolase Deficiency Dihydropyrimidinuria Due To Dpys Deficiency
Blepharophimosis, Ptosis, And Epicanthus Inversus	Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome BPES Blepharophimosis Syndrome Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 1 Blepharophimosis, Ptosis, Epicanthus Inversus Syndrome Bpes With Duane Retraction Syndrome Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 2 Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 1 Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 2 Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 2 Bpes Type 2 Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Without Premature Ovarian Failure Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus 3q23 Microdeletion Syndrome Bpes Plus Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 1 Bpes Type 1 Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome With Premature Ovarian Failure Blepharophimosis, Ptosis, Epicanthus Inversus Autosomal Dominant Bpes Type I Autosomal Recessive Bpes Type I Bpes Type I Bpes Type Ii Bpes Without Ovarian Failure Bpes With Ovarian Failure Blepharophimosis Syndrome Type 1 Blepharophimosis Syndrome Type 2
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS13587	SOX14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SOX14	RGD	RGD:1309654
Mus musculus	SOX14	MGD	MGI:98362
Macaca mulatta	SOX14	VGNC	VGNC:77840
Bos taurus	SOX14	VGNC	VGNC:106946
Felis catus	SOX14	VGNC	VGNC:102847
Others	SOX14	NCBI