TP53I3 - tumor protein p53 inducible protein 3 Gene

Also Known as PIG3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9540

About TP53I3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,077,433-24,084,834 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and 17 paralogues. Broad expression in esophagus (RPKM 29.3), small intestine (RPKM 17.8) and 24 other tissues.

Summary

The protein encoded by this gene is similar to oxidoreductases, which are Enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to Cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

TP53I3 Products (3)

mRNA Protein Name
NM_001206802.2 NP_001193731.1 quinone oxidoreductase PIG3 isoform 2
NM_004881.5 NP_004872.2 quinone oxidoreductase PIG3 isoform 1
NM_147184.4 NP_671713.1 quinone oxidoreductase PIG3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
enables NADPH binding IDA
IDA: Inferred from direct assay
19349281 GOA
enables NADPH:quinone reductase activity IDA
IDA: Inferred from direct assay
19349281 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19349281 GOA
enables quinone binding IDA
IDA: Inferred from direct assay
19349281 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in NADP metabolic process IDA
IDA: Inferred from direct assay
19349281 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53I3 Protein Structure

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (28 - 88)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (152 - 277)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

quinone oxidoreductase PIG3

  • NADPH:quinone reductase PIG3

Recombinant TP53I3 Proteins

Referencia número Nombre del producto Accession Pureza
HY-P74632 PIG3 Protein, Human (His) Q53FA7 (M1-Q332) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ewing Sarcoma

  • Neuroepithelioma

  • Ewing'S Tumor

  • Primitive Neuroectodermal Tumor

  • Ewings Sarcoma

  • Ewing'S Sarcoma

  • Peripheral Neuroepithelioma

  • ES

  • Ewings Sarcoma-Primitive Neuroectodermal Tumor

  • Localized Peripheral Primitive Neuroectodermal Tumor

  • Peripheral Primitive Neuroectodermal Tumor

  • Ewing Tumor

  • Sarcoma, Ewing'S

  • Ewing Family Of Tumors

  • Extraosseous Ewing Tumor

  • Askin Tumor

  • Ewing'S Family Localized Tumor

  • Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing Sarcoma

  • Localized Ewing'S Sarcoma

  • Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing'S Tumor

  • Pnet Of Thoracopulmonary Region

  • Tumor Of The Ewing Family

  • Skeletal Ewing Sarcoma

  • Osseous Ewing Sarcoma

  • Ppnet

  • Peripheral Pnet

  • Extraskeletal Ewing Sarcoma

  • Eoe

  • Extraosseous Ewing Sarcoma

  • Extraskeletal Ewing Tumor

  • Esft

  • Ewing Sarcoma Family Of Tumors

  • Pne

  • Pnet

  • Pnet Of The Chest Wall

  • Sarcoma, Ewing

  • Neuroectodermal Tumors, Primitive, Peripheral

  • Neuroectodermal Tumor, Primitive

  • Disorder Of Eye

  • Askin'S Tumor

  • Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

  • Neuroepithelioma, Peripheral
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS14919 TP53I3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26028 Tp53i3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TP53I3 VGNC VGNC:47724
Rattus norvegicus TP53I3 RGD RGD:41235940
Macaca mulatta TP53I3 VGNC VGNC:79194
Bos taurus TP53I3 VGNC VGNC:36235
Felis catus TP53I3 VGNC VGNC:66464
Others TP53I3 NCBI