Kv3 activator-1
Based on 1 Customer Validation
Kv3 activator-1 is a Kv3 family voltage-gated potassium channel activator. Kv3 activator-1 reverses mechanical hyperalgesia in rat models of neuropathic and inflammatory pain, with rapid onset and long-lasting, dose-related effects. Kv3 activator-1 can be used for the research of pain.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.41%
- No. CAS: 1380696-64-9
- Fòrmula: C20H20N4O4
- Peso molecular:380.40
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Kv3 activator-1 (Compound X) increased whole-cell currents of Kv3.1 and Kv3.2 potassium channels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Kv3 activator-1 (10-60 mg/kg; i.p.; single dose) produces a dose-dependent reversal of mechanical hyperalgesia in a rat model of inflammatory pain, with peak efficacy of 92% reversal at the 60 mg/kg dose[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar Hanover (male, 225g, partial sciatic nerve ligation)[1]
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Dosage:10 mg/kg; 30 mg/kg; 60 mg/kg
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Administration:i.p.; single dose
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Result:Produced a dose-related reversal of mechanical sensitivity.
Reached peak reversal of 31% at 10 mg/kg, 73% at 30 mg/kg, and 81% at 60 mg/kg at 3 hours post-dose.
Increased contralateral paw withdrawal thresholds to mechanical pressure significantly.
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Animal Model:Wistar Hanover (male, 225g, intraplantar Freund's Complete Adjuvant (HY-153808) injection)[1]
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Dosage:10 mg/kg; 30 mg/kg; 60 mg/kg
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Administration:i.p.; single dose
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Result:Produced a dose-related reversal of mechanical sensitivity with rapid onset.
Reached peak reversal of 64% at 10 mg/kg at 3 hours post-dose, 74% at 30 mg/kg and 92% at 60 mg/kg at 1 hour post-dose.
Maintained significant reversal of 45% at 6 hours post-dose with 60 mg/kg.
Chemical Information
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No. CAS 1380696-64-9
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Appearance Solid
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Peso molecular 380.40
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Fòrmula C20H20N4O4
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Color White to light yellow
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SMILES
O=C1N(C2=CN=C(OC3=C4C5(CC5)COC4=C(C)C=C3)N=C2)C(C(C)(C)N1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kv3 activator-1 Related Classifications
HY-111996 Related Classifications
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- Kv3 activator-1
- 1380696-64-9
- Potassium Channel
- Kv3.3 voltage-gated potassium channels
- Kv3 family voltage-gated potassium channel
- Kv3.1 voltage-gated potassium channels
- inflammatory pain
- whole-cell currents
- anti-hyperalgesic agent
- rat models
- Kv3.2 voltage-gated potassium channels
- mechanical hyperalgesia
- neuropathic pain
- Inhibitor
- inhibitor
- inhibit