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Referencia número: HY-177541

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Ledadotin

Ledadotin is a drug-linker conjugate for ADC. Ledadotin consists of a Microtubule inhibitor (Auristatin F-hydroxypropylamide) (HY-P5191) and a linker (BCN-PEG2-Gly-NH-tri(βAla-GGGG-Ser(mPEG8)-βAla-γGlu-Ala)) (HY-177562). Ledadotin can be used for synthesis of ADC Emiltatug ledadotin (HY-177542).

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No. CAS: 2669084-60-8
Fòrmula: C₂₉₄H₄₉₄N₅₂O₁₀₀
Peso molecular:6357.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Ledadotin Chemical Structure

No. CAS: 2669084-60-8

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Use of MCE Products

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Drug-Linker Conjugates for ADC :

Chemical Information

No. CAS 2669084-60-8
Peso molecular 6357.36
Fòrmula C₂₉₄H₄₉₄N₅₂O₁₀₀
SMILES

O=C(NCCC(NCC(NCC(NCC(NCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOC)=O)COC(NCCC(N[C@H](C(O)=O)CCC(N[C@H](C(OCCCNC([C@@H](CC1=CC=CC=C1)NC([C@H]([C@H](OC)[C@H]2CCCN2C(C[C@@H]([C@@H]([C@@H](CC)C)N(C([C@@H](C(C)C)NC([C@@H](C(C)C)N(C)C)=O)=O)C)OC)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CCOCC(COCCC(NCCC(NCC(NCC(NCC(NCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOC)=O)COC(NCCC(N[C@H](C(O)=O)CCC(N[C@H](C(OCCCNC([C@@H](CC3=CC=CC=C3)NC([C@H]([C@H](OC)[C@H]4CCCN4C(C[C@@H]([C@@H]([C@@H](CC)C)N(C([C@@H](C(C)C)NC([C@@H](C(C)C)N(C)C)=O)=O)C)OC)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)(COCCC(NCCC(NCC(NCC(NCC(NCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOC)=O)COC(NCCC(N[C@H](C(O)=O)CCC(N[C@H](C(OCCCNC([C@@H](CC5=CC=CC=C5)NC([C@H]([C@H](OC)[C@H]6CCCN6C(C[C@@H]([C@@H]([C@@H](CC)C)N(C([C@@H](C(C)C)NC([C@@H](C(C)C)N(C)C)=O)=O)C)OC)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CNC(CCC(NCCOCCOCCNC(OC[C@H]7[C@]8(CCC#CCC[C@]87[H])[H])=O)=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Toader D, et al. Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer. Mol Cancer Ther. 2023 Sep 5;22(9):999-1012. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
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Referencias

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Ledadotin

Ver todos los productos específicos de isoformas Drug-Linker Conjugates for ADC