Leoidin
Leoidin is an OATP1B1 and OATP1B3 inhibitor with Ki values of 0.08 and 1.84 μM, respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC50= 42 μM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides.
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- No. CAS: 105350-54-7
- Fòrmula: C18H14Cl2O7
- Peso molecular:413.21
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 105350-54-7
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Peso molecular 413.21
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Fòrmula C18H14Cl2O7
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SMILES
O=C(C1=C(O)C(C)=C(C(OC2=C(Cl)C(O)=C(Cl)C(C)=C23)=C1C)OC3=O)OC
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Structure Classification
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Initial Source
Lecanora gangaleoides
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. De Bruyn T, et al. Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol. 2013 Jun;83(6):1257-67. [Content Brief]
[2]. Hu Y, et al. Discovery and Analysis of Natural-Product Compounds Inhibiting Protein Synthesis in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4820-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leoidin Related Classifications
HY-N8497 Related Classifications
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