NARS-3′
NARS-3′ is an orally active reversible xanthine oxidase (XO) inhibitor with the IC50 of 21.01 μM. NARS-3′ can competitively inhibit XO activity and reduce uric acid production. NARS-3′ can reduce renal damage in hyperuricemia mice. NARS-3′ can be used for the study of hyperuricemia.
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- No. CAS: 2702589-46-4
- Fòrmula: C15H11NaO8S
- Peso molecular:374.30
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
NARS-3′ (0-100 μM) exhibits dose-dependent inhibition on XO activity[1].
NARS-3′ (0-40 μM) can bind to the active site of XO and compete with xanthine substrates during the catalytic process[1].
NARS-3′ could cause the conformational changes in XO[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Potassium oxonate (250 mg/kg) injected the male Kunming mice (4 weeks)[1].
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Dosage:0.3 % carboxymethyl cellulose sodium solution
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Administration:Oral gavage (i.g.); once daily for a week
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Result:Reduced serum UA levels to 56.26 μM and reduced XO activity to 9.21 U/L.
Lowered serum CRE levels to 7.85 μM and reduce pathological damage to the kidneys.
Chemical Information
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No. CAS 2702589-46-4
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Peso molecular 374.30
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Fòrmula C15H11NaO8S
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SMILES
O=C1CC(OC2=CC(O)=CC(O)=C12)C3=CC(S(=O)(O[Na])=O)=C(C=C3)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NARS-3′ Related Classifications
HY-174318 Related Classifications
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