PPAR agonist 5
Based on 1 Customer Validation
PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC50 values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 97.16%
- No. CAS: 3059387-62-8
- Fòrmula: C26H29NO3
- Peso molecular:403.51
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
PPARα 3.20 μM (EC50) |
PPARβ/δ 1.51 μM (EC50) |
PPARγ 1.92 μM (EC50) |
In Vitro
PPAR agonist 5 (compound 4b) (10 µM; 4, 24 h) decrease LPS (HY-D1056) induced mRNA expression of CCL-2 and IL-6[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:THP-1 human monocytes differentiated into macrophages
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Concentration:10 µM
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Incubation Time:4, 24 h
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Result:Decreased the LPS (HY-D1056) (10 ng/mL)-induced expression of CCL-2 at 4 and 24 h and the expression of IL-6 at 24 h.
Chemical Information
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No. CAS 3059387-62-8
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Appearance Liquid
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Peso molecular 403.51
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Fòrmula C26H29NO3
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Color Light yellow to brown
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SMILES
O=C(OCC)CC/C(C)=C/CCC1=NC2=CC=C(OCC3=CC=CC=C3)C=C2C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (123.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4783 mL | 12.3913 mL | 24.7825 mL | 61.9563 mL |
| 5 mM | 0.4957 mL | 2.4783 mL | 4.9565 mL | 12.3913 mL | |
| 10 mM | 0.2478 mL | 1.2391 mL | 2.4783 mL | 6.1956 mL | |
| 15 mM | 0.1652 mL | 0.8261 mL | 1.6522 mL | 4.1304 mL | |
| 20 mM | 0.1239 mL | 0.6196 mL | 1.2391 mL | 3.0978 mL | |
| 25 mM | 0.0991 mL | 0.4957 mL | 0.9913 mL | 2.4783 mL | |
| 30 mM | 0.0826 mL | 0.4130 mL | 0.8261 mL | 2.0652 mL | |
| 40 mM | 0.0620 mL | 0.3098 mL | 0.6196 mL | 1.5489 mL | |
| 50 mM | 0.0496 mL | 0.2478 mL | 0.4957 mL | 1.2391 mL | |
| 60 mM | 0.0413 mL | 0.2065 mL | 0.4130 mL | 1.0326 mL | |
| 80 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7745 mL | |
| 100 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6196 mL |
PPAR agonist 5 Related Classifications
HY-163547 Related Classifications
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