RC363
RC363 is a glutathione peroxidase 1 (GPx1) activator. RC363 enhances glutathione peroxidase activity and inhibits ferroptosis. RC363 can be used for the research of neurodegenerative conditions.
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- No. CAS: 2584411-86-7
- Fòrmula: C18H24OS2
- Peso molecular:320.51
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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GPX1 |
RC363 (0.0625-3 μM; 1-48 h) inhibits glutamate-induced cytotoxicity in HT-22 cells[1].
RC363 (3 μM; 6 h) does not significantly decrease oxidant levels in HT-22 cells[1].
RC363 (3 μM; 24 h) significantly increases the protein level of GPx1 in HT-22 cells[1].
RC363 (0.0625-1 μM; 24 h) inhibits RSL3 (HY-100218A)-induced ferroptosis in HT-22 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-22 cells, primary cortical neurons
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Concentration:3 μM
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Incubation Time:48 h
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Result:Exhibited no cytotoxicity to HT-22 cells.
Inhibited glutamate-induced ferroptosis.
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Cell Line:HT-22 cells
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Concentration:0.0625 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM
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Incubation Time:1 h; 2 h; 4 h; 6 h; 8 h
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Result:Exhibited fully protective at the concentration of ≥0.5 μM.
Presented significant protective effects when added simultaneously with glutamate. Gradually lost protection when the compound was added longer periods after the challenge.
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Cell Line:HT-22 cells
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Concentration:3 μM
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Incubation Time:24 h
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Result:Significantly increased the protein level of GPx1.
Chemical Information
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No. CAS 2584411-86-7
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Peso molecular 320.51
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Fòrmula C18H24OS2
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SMILES
OC1=C(C(C)(C)C)C=C(SC2=CC=CS2)C=C1C(C)(C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RC363 Related Classifications
HY-139008 Related Classifications
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