SB-1295
SB-1295 is an orally active CDK9/T1 inhibitor (IC50=0.17 μM). SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C23H22ClNO6
- Peso molecular:443.88
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
IC50: 0.17 μM (CDK9/T1)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
5.1 μM
Compound: 2b; SB-1295, DD-35
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Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
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[PMID: 37302342] |
| HEK293 | GI50 |
90.32 μM
Compound: 2b; SB-1295, DD-35
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Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
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[PMID: 37302342] |
| MIA PaCa-2 | GI50 |
6.07 μM
Compound: 2b; SB-1295, DD-35
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Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
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[PMID: 37302342] |
Chemical Information
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Peso molecular 443.88
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Fòrmula C23H22ClNO6
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SMILES
OC1=C2C(OC(/C=C/C3=CC=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)C[N+](C)([O-])CC4)C(O)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB-1295 Related Classifications
HY-155065 Related Classifications
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