SNAP-6201
SNAP-6201 is a selective α1a adrenoceptor antagonist with a Ki of 0.2 nM. SNAP-6201 exhibits >1400-fold selectivity over α1b and α1d adrenoceptors. SNAP-6201 exhibits excellent selectively to inhibit intraurethral pressure (IUP) in the anesthetized dog model. SNAP-6201 can be used for benign prostatic hyperplasia (BPH) research.
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- No. CAS: 252201-38-0
- Fòrmula: C30H35F2N5O5
- Peso molecular:583.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Adrenergic Receptor
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Actividad biológica
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α1A-adrenergic receptor 0.2 nM (Ki) |
α1B-adrenergic receptor 260 nM (Ki) |
α1D-adrenergic receptor 350 nM (Ki) |
rat α1A-adrenergic receptor 0.27 nM (Ki) |
SNAP-6201 (compound 103) shows comparable binding affinity at the recombinant rat, dog, and human α1a adrenoceptors, with Kis of 0.3, 1.3, and 0.2 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 252201-38-0
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Peso molecular 583.63
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Fòrmula C30H35F2N5O5
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SMILES
COC(C1(C2=CC=CC=C2)CCN(CCCNC(N3C(NC(CC)=C(C(N)=O)C3C4=CC(F)=C(F)C=C4)=O)=O)CC1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SNAP-6201 Related Classifications
HY-W724254 Related Classifications
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