Vorsetuzumab mafodotin
Vorsetuzumab mafodotin (SGN-75) is an Auristatin-based anti-CD70 antibody-drug conjugate (ADC). Vorsetuzumab mafodotin consists of a humanized monoclonal antibody, Vorsetuzumab and an ADC cytotoxin MMAF. Vorsetuzumab mafodotin has antineoplastic activity.
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- No. CAS: 1165741-01-4
- Peso molecular:150 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
Vorsetuzumab mafodotin (SGN-75; 0.01-10000 ng/mL; for 96 h) induces dose-dependent cytotoxicity that is specific with an IC50 of 29 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:SK-OV-3 cells
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Concentration:0.01 ng/mL, 0.1 ng/mL, 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL, 10000 ng/mL
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Incubation Time:96 h
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Result:Induced dose-dependent cytotoxicity.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude (nu/nu) female mice injected with MiaPaCa-2/CD70 tumour pieces[1]
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Dosage:3 mg/kg
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Administration:Intraperitoneal injection; every 4 days; for a total of four doses
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Result:Significantly reduced median tumour volumes and delayed tumour growth.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1165741-01-4
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Appearance Liquid
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Peso molecular 150 kDa
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Color Colorless to light yellow
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SMILES
[Vorsetuzumab mafodotin]
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Synonyms
Anti-Human CD70 Recombinant Antibody; SGN-75
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Envío
Shipping with dry ice.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Vorsetuzumab mafodotin Related Classifications
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