Nlrp6 - NLR family, pyrin domain containing 6 Gene

Also Known as Avr; Navr; Nalp6; Pypaf5; Non-AVR; Navr/Avr

Species: Mus musculus

Gene Type: protein coding
Gene ID: 101613

Summary

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]

Nlrp6 Products (1)

mRNA Protein Name
NM_133946.2 NP_598707.2 NACHT, LRR and PYD domains-containing protein 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
34678144 MGI
enables lipoteichoic acid binding IDA
IDA: Inferred from direct assay
30392956 MGI
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
34678144 MGI
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
34678144 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26494172 MGI
Biological Process GO Annotation Evidence References Source
involved in NLRP6 inflammasome complex assembly IDA
IDA: Inferred from direct assay
32424362 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
30248149 MGI
acts upstream of or within acute inflammatory response IMP
IMP: Inferred from mutant phenotype
30248149 MGI
acts upstream of or within acute inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
30248149 MGI
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
34678144 MGI
involved in antiviral innate immune response IMP
IMP: Inferred from mutant phenotype
26494172 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
30392956 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
26494172 MGI
NOT involved in host-mediated regulation of intestinal microbiota composition IMP
IMP: Inferred from mutant phenotype
28801232 MGI
involved in host-mediated regulation of intestinal microbiota composition IMP
IMP: Inferred from mutant phenotype
26638072 MGI
acts upstream of or within interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
30248149 MGI
acts upstream of or within interleukin-18 production IMP
IMP: Inferred from mutant phenotype
30248149 MGI
acts upstream of or within necroptotic process IMP
IMP: Inferred from mutant phenotype
30248149 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
22763455 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
22763455 MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22763455 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22763455 MGI
acts upstream of or within negative regulation of immune response IMP
IMP: Inferred from mutant phenotype
22763455 MGI
involved in negative regulation of inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
22763455 MGI
acts upstream of or within negative regulation of toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22763455 MGI
acts upstream of or within negative regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
30248149 MGI
acts upstream of or within neutrophil-mediated killing of gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
30248149 MGI
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
26494172 MGI
involved in positive regulation of interleukin-18-mediated signaling pathway IDA
IDA: Inferred from direct assay
30392956 MGI
involved in positive regulation of interleukin-18-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
26638072 MGI
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
34678144 MGI
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
34678144 MGI
acts upstream of or within pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
30248149 MGI
acts upstream of or within regulation of autophagy IMP
IMP: Inferred from mutant phenotype
24581500 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
23696660 MGI
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
21543645 MGI
acts upstream of or within regulation of mucus secretion IMP
IMP: Inferred from mutant phenotype
24581500 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
23075849 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
21593405 MGI
Cellular Component GO Annotation Evidence References Source
part of NLRP6 inflammasome complex IDA
IDA: Inferred from direct assay
32424362 MGI
part of canonical inflammasome complex IDA
IDA: Inferred from direct assay
30248149 MGI
is active in non-membrane-bounded organelle IDA
IDA: Inferred from direct assay
34678144 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 6

  • NACHT, leucine rich repeat and PYD containing 6

  • NACHT/LRR/pyrin domain-containing protein 6

  • PYRIN-containing APAF1-like protein 5

  • angiotensin II/vasopressin receptor

  • non-angiotensin-vasopressin receptor

Nlrp6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nlrp6 Q91WS2 Dhx15 Mus musculus O35286
Anti Bait CoIP
26494172
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09362 NLRP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17708 Nlrp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24173 Nlrp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlrp6 NCBI NCBI:171389