Slc6a8 - solute carrier family 6 (neurotransmitter transporter, creatine), member 8 Gene

Also Known as CRT; CT1; CRTR; CTR5; Creat

Species: Mus musculus

Gene Type: protein coding
Gene ID: 102857

Summary

Predicted to enable choline transmembrane transporter activity and creatine:sodium symporter activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to act upstream of or within creatine transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study creatine transporter deficiency. Human ortholog(s) of this gene implicated in creatine transporter deficiency and intellectual disability. Orthologous to human SLC6A8 (solute carrier family 6 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a8 Products (3)

mRNA Protein Name
NM_001142809.1 NP_001136281.1 sodium- and chloride-dependent creatine transporter 1 isoform 2
NM_001142810.1 NP_001136282.1 sodium- and chloride-dependent creatine transporter 1 isoform 3
NM_133987.2 NP_598748.1 sodium- and chloride-dependent creatine transporter 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables creatine:sodium symporter activity IDA
IDA: Inferred from direct assay
12439290 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium- and chloride-dependent creatine transporter 1

  • creatine transporter 1

  • creatine transporter, solute carrier family 6, member 8

  • solute carrier family 6, member 8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W015828 Ompenaclid Inducer 99.94% Phase 3

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169294 SLC6A8 corrector 1 Inhibitor 99.94% Unkown
HY-RS13319 SLC6A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158161 JN-170 Inhibitor / Unkown
HY-169295 RAP 1 / Unkown
HY-181753 INSP-0154 / Unkown
HY-W695425 Creatine transporter-IN-1 Inhibitor / Unkown
HY-RS17671 Slc6a8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24132 Slc6a8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a8 NCBI NCBI:6535