B3GALT5 - beta-1,3-galactosyltransferase 5 Gene

Also Known as B3T5; GLCT5; B3GalTx; B3GalT-V; beta3Gal-T5; beta-3-Gx-T5; beta-1,3-GalTase 5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10317

About B3GALT5

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:39,612,940-39,673,137 (from NCBI)

This gene has 11 transcripts (splice variants), 313 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 5.1), colon (RPKM 4.2) and 3 other tissues.

Summary

This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]

B3GALT5 Products (8)

mRNA Protein Name
NM_001278650.2 NP_001265579.1 beta-1,3-galactosyltransferase 5 isoform a
NM_001356336.2 NP_001343265.1 beta-1,3-galactosyltransferase 5 isoform a
NM_001356338.2 NP_001343267.1 beta-1,3-galactosyltransferase 5 isoform a
NM_001356339.2 NP_001343268.1 beta-1,3-galactosyltransferase 5 isoform a
NM_006057.3 NP_006048.1 beta-1,3-galactosyltransferase 5 isoform a
NM_033170.3 NP_149360.1 beta-1,3-galactosyltransferase 5 isoform a
NM_033171.3 NP_149361.1 beta-1,3-galactosyltransferase 5 isoform a
NM_033172.3 NP_149362.2 beta-1,3-galactosyltransferase 5 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

B3GALT5 Protein Structure

Galactosyl_T

Galactosyl_T: Galactosyltransferase (72 - 260)

  • 0
  • 100
  • 200
  • 310 a.a.
Protein Preferred Names Protein Names

beta-1,3-galactosyltransferase 5

  • UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5

B3GALT5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
B3GALT5 Q9Y2C3 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
Intra
B3GALT5 Q9Y2C3 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
Intra
B3GALT5 Q9Y2C3 DEFB103A Homo sapiens P81534
Y2H Array
32296183
Intra
B3GALT5 Q9Y2C3 DEFB103A Homo sapiens P81534
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant B3GALT5 Proteins

Cat. No. Product Name Accession Purity
HY-P76738 B3GALT5 Protein, Human (HEK293, Fc) Q9Y2C3 (N29-V310) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P76739 B3GALT5 Protein, Human (sf9, His) Q9Y2C3 (N29-V310) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01305 B3GALT5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20622 B3galt5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27131 B3galt5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus B3GALT5 VGNC VGNC:56202
Canis familiaris B3GALT5 VGNC VGNC:38336
Macaca mulatta B3GALT5 VGNC VGNC:70206
Felis catus B3GALT5 VGNC VGNC:68955
Rattus norvegicus B3GALT5 RGD RGD:1306727
Mus musculus B3GALT5 MGD MGI:2136878
Others B3GALT5 NCBI