Fbxo4 - F-box protein 4 Gene

Also Known as Fbx4; 1700096C12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 106052

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; positive regulation of protein polyubiquitination; and protein destabilization. Part of SCF ubiquitin Ligase complex. Is expressed in several structures, including craniocervical region bone; esophagus; lung; pituitary gland; and sensory organ. Orthologous to human FBXO4 (F-box protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Fbxo4 Products (1)

mRNA	Protein	Name
NM_134099.2	NP_598860.2	F-box only protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21242966	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21911473	MGI
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	29142209	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular homeostasis	IMP IMP: Inferred from mutant phenotype	21911473	MGI
acts upstream of or within cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	21911473	MGI
acts upstream of or within cellular senescence	IMP IMP: Inferred from mutant phenotype	21911473	MGI
acts upstream of or within common myeloid progenitor cell proliferation	IMP IMP: Inferred from mutant phenotype	21911473	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	21911473	MGI
acts upstream of or within negative regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	21911473	MGI
acts upstream of or within positive regulation of protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	21911473	MGI
acts upstream of or within post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21911473	MGI
acts upstream of or within protein destabilization	IMP IMP: Inferred from mutant phenotype	21911473	MGI
acts upstream of or within regulation of DNA damage checkpoint	IMP IMP: Inferred from mutant phenotype	21911473	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	21911473	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
F-box only protein 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04806	FBXO4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18517	Fbxo4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24999	Fbxo4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fbxo4	NCBI	NCBI:26272