CES1 - carboxylesterase 1 Gene

Homo sapiens

Also known as CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1

Gene ID: 1066 | Gene type: protein coding

About CES1

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,802,851-55,833,096 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 667 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 737.7), gall bladder (RPKM 239.9) and 3 other tissues.

Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and Cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This Enzyme is the major liver Enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

CES1 Products(3)

mRNA	Protein	Name
NM_001025194.2	NP_001020365.1	liver carboxylesterase 1 isoform b precursor
NM_001025195.2	NP_001020366.1	liver carboxylesterase 1 isoform a precursor
NM_001266.5	NP_001257.4	liver carboxylesterase 1 isoform c precursor

CES1 Protein Structure

COesterase

0
100
200
300
400
500
567 a.a.

Protein Preferred Names

Protein Names

liver carboxylesterase 1

acyl coenzyme A:cholesterol acyltransferase

Recombinant CES1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7730	Carboxylesterase 1 Protein, Human (HEK293, His)	P23141-3 (H19-H564)	≥95%

Related Diseases

Diseases

Alias

Drug Metabolism, Altered, Ces1-Related

Egasyn

Esterase 22

Es22

Alveolar Echinococcosis

Echinococcus Multilocularis Infection	Echinococcosis
Alveolococcosis	Multilocular Hydatid
Small Fox Tapeworm

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

Reye Syndrome

Reye'S Syndrome	Rasmussen Encephalitis
Fatty Liver With Encephalopathy	Rasmussen'S Encephalitis
Re	Rs
Rasmussen Syndrome	Liver Fatty Metamorphosis--Acute Encephalopathy Syndrome
Reye Encephalopathy

Large Intestine Adenoma

Adenoma Of Large Intestine

Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis

Echinococcosis

Hydatidosis	Echinococcal Disease
Echinococcosis Of Liver	Hepatic Echinococcosis
Hydatid Disease	Liver Echinococcus
Pulmonary Echinococcosis	Hydatids
Echinococcosis, Hepatic	Echinococcosis, Pulmonary
Unilocular Echinococcosis	Echinococcus Disease
Echinococcus Granulosus Infection	Echinococcus Multilocularis Infection
Dog Tapeworm Infection	Echinococcus Granulosus Infestation
Echinococciasis	Cystic Echinococcosis

Taeniasis

Beef Tapeworm Infection	Infection By Taeniarhynchus Saginatus
Taenia Saginata Infectious Disease	Taenia Saginata Infection
Pork Tapeworm Infection	Armed Tapeworm Infection
Infection By Taenia Solium	Intestinal Taenia Solium Infection
Pork Tapeworm	Taenia Solium Taeniasis
Adult Pork Tapeworm Infection	Adult Pork Tapeworm
Beef Tapeworm	Infection By Taenia Saginata
Unarmed Tapeworm Infection	Taenia Saginata Taeniasis
Infection Due To Adult Tapeworm Taenia Saginata	Mediocanellata Taenia Infection
Infestation By Taenia Saginata	Infestation By Taenia Mediocanellata

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis	Niemann-Pick Diseases
Lipoid Histiocytosis	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency Disease	Lipid Histiocytosis
Neuronal Cholesterol Lipidosis	Neuronal Lipidosis
Npd	Sphingomyelinase Deficiency
Niemann-Pick Disease, Type A

Retinitis Pigmentosa 44

RP44	Retinitis Pigmentosa, Type 44

Glossopharyngeal Neuralgia

Glossopharyngeal Nerve Diseases

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Cysticercosis

Neurocysticercosis	Submacular Cysticercosis
Intestinal Taenia Solium Infection	Pork Tapeworm Infection
Tapeworm Infection: Intestinal Taenia Solum	Tapeworm Infection: Pork
Tenia Solium Infectious Disease	Taeniasis
Tenia Solium Infection	Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0384	Temocapril hydrochloride	Inhibitor	99.83%	Unkown
HY-100713	Temocapril	Inhibitor	98.14%	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110148	WWL113	Inhibitor	99.08%	Unkown
HY-147763	HCV-IN-39	Inhibitor	/	Unkown
HY-147331	Oseltamivir acid methyl ester		/	Unkown
HY-147764	HCV-IN-40	Inhibitor	/	Unkown
HY-N10686	Tanshinone IIA anhydride	Inhibitor	/	Unkown
HY-RS02543	CES1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CES1	VGNC	VGNC:52121
Rattus norvegicus	CES1	RGD	RGD:70896
Mus musculus	CES1	NCBI

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