POLD3 - DNA polymerase delta 3, accessory subunit Gene

Also Known as P66; P68; PPP1R128

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10714

About POLD3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,592,582-74,669,341 (from NCBI)

This gene has 10 transcripts (splice variants) and 37 orthologues. Ubiquitous expression in testis (RPKM 7.5), colon (RPKM 6.2) and 25 other tissues.

Summary

This gene encodes the 66-kDa subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA Polymerase delta through interactions with Other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

POLD3 Products (2)

mRNA	Protein	Name
NM_001363597.2	NP_001350526.1	DNA polymerase delta subunit 3 isoform 2
NM_006591.3	NP_006582.1	DNA polymerase delta subunit 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15576034	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	11595739	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA biosynthetic process	IDA IDA: Inferred from direct assay	11595739	GOA
involved in DNA-templated DNA replication	IDA IDA: Inferred from direct assay	20334433	GOA
involved in error-prone translesion synthesis	IDA IDA: Inferred from direct assay	24449906	GOA
involved in nucleotide-excision repair, DNA gap filling	IMP IMP: Inferred from mutant phenotype	20227374	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of delta DNA polymerase complex	IDA IDA: Inferred from direct assay	11595739	GOA
part of delta DNA polymerase complex	IPI IPI: Inferred from physical interaction	12403614	GOA
part of zeta DNA polymerase complex	IDA IDA: Inferred from direct assay	22465957	GOA
part of zeta DNA polymerase complex	IPI IPI: Inferred from physical interaction	24449906	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLD3 Protein Structure

CDC27

0
100
200
300
400
466 a.a.

Protein Preferred Names	Protein Names
DNA polymerase delta subunit 3	DNA polymerase delta subunit C

POLD3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POLD3	Q15054	PCNA	Homo sapiens	P12004	Anti Tag CoIP	16000169
Intra	POLD3	Q15054	POLD2	Homo sapiens	P49005	Anti Bait CoIP	16000169
Intra	POLD3	Q15054	POLD2	Homo sapiens	P49005	Y2H	16000169

Cross: Cross-species interaction Intra: Intraspecies interaction

POLD3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810971	DNA Polymerase delta 3 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ruijs-Aalfs Syndrome	Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome RJALS
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Chronic Fatigue Syndrome	Myalgic Encephalomyelitis Postviral Fatigue Syndrome Cfs Myalgic Encephalitis Encephalomyelitis, Myalgic Chronic Fatigue Fatigue Syndrome, Chronic Benign Myalgic Encephalomyelitis Akureyri Akureyri Disease Cfs - [Chronic Fatigue Syndrome] Epidemic Neuromyasthenia Myalgic Encephalomyelitis Syndrome Me - [Myalgic Encephalomyelitis] Pvfs - [Postviral Fatigue Syndrome] Neuromyasthenia Iceland Disease Icelandic Disease
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-183488	R9-caPep		/	Unkown
HY-RS10821	POLD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21694	Pold3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28212	Pold3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POLD3	VGNC	VGNC:33115
Macaca mulatta	POLD3	VGNC	VGNC:101381
Mus musculus	POLD3	MGD	MGI:1915217
Felis catus	POLD3	VGNC	VGNC:64283
Rattus norvegicus	POLD3	RGD	RGD:1312027
Canis familiaris	POLD3	VGNC	VGNC:44776
Others	POLD3	NCBI