2. Gene
  3. POLD2 - DNA polymerase delta 2, accessory subunit Gene

POLD2 - DNA polymerase delta 2, accessory subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 5425 | Gene type: protein coding

About POLD2

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,114,680-44,124,325 (from NCBI)

This gene has 68 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in heart (RPKM 20.0), ovary (RPKM 19.1) and 25 other tissues.

Summary

This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

POLD2 Products(3)

mRNA Protein Name
NM_001127218.3 NP_001120690.1 DNA polymerase delta subunit 2
NM_001256879.2 NP_001243808.1 DNA polymerase delta subunit 2
NM_006230.4 NP_006221.3 DNA polymerase delta subunit 2

POLD2 Protein Structure

DNA_pol_E_B

DNA_pol_E_B: DNA polymerase alpha/epsilon subunit B (196 - 411)

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  • 469 a.a.
Protein Preferred Names Protein Names

DNA polymerase delta subunit 2

DAN polymerase delta 2, accessory subunit

Recombinant POLD2 Proteins

Cat. No. Product Name Accession Purity
HY-P71220 POLD2 Protein, Human (His) P49005 (M1-P469) ≥95%

Related Diseases

Diseases Alias
Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10820 POLD2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta POLD2 VGNC VGNC:76203
Bos taurus POLD2 VGNC VGNC:33114
Felis catus POLD2 VGNC VGNC:68937
Mus musculus POLD2 MGD MGI:1097163
Canis familiaris POLD2 VGNC VGNC:44775
Rattus norvegicus POLD2 RGD RGD:1304954