POLD2 - DNA polymerase delta 2, accessory subunit Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5425

About POLD2

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,114,680-44,124,325 (from NCBI)

This gene has 68 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in heart (RPKM 20.0), ovary (RPKM 19.1) and 25 other tissues.

Summary

This gene encodes the 50-kDa catalytic subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA Polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

POLD2 Products (3)

mRNA	Protein	Name
NM_001127218.3	NP_001120690.1	DNA polymerase delta subunit 2
NM_001256879.2	NP_001243808.1	DNA polymerase delta subunit 2
NM_006230.4	NP_006221.3	DNA polymerase delta subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12403614	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA biosynthetic process	IDA IDA: Inferred from direct assay	11595739	GOA
involved in DNA-templated DNA replication	IDA IDA: Inferred from direct assay	20334433	GOA
involved in error-prone translesion synthesis	IDA IDA: Inferred from direct assay	24449906	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of delta DNA polymerase complex	IDA IDA: Inferred from direct assay	11595739	GOA
part of delta DNA polymerase complex	IPI IPI: Inferred from physical interaction	12403614	GOA
part of zeta DNA polymerase complex	IDA IDA: Inferred from direct assay	22465957	GOA
part of zeta DNA polymerase complex	IPI IPI: Inferred from physical interaction	24449906	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLD2 Protein Structure

DNA_pol_E_B

0
100
200
300
400
469 a.a.

Protein Preferred Names	Protein Names
DNA polymerase delta subunit 2	DAN polymerase delta 2, accessory subunit

POLD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POLD2	P49005	POLD1	Homo sapiens	P28340	Pull Down	31449058
Intra	POLD2	P49005	POLD1	Homo sapiens	P28340	Anti Tag CoIP	33961781
Intra	POLD2	P49005	POLD1	Homo sapiens	P28340	Anti Tag CoIP	31449058
Intra	POLD2	P49005	POLD1	Homo sapiens	P28340	Anti Tag CoIP	28514442
Intra	POLD2	P49005	POLD1	Homo sapiens	P28340	Ion Exchange Chrom	12403614
Intra	POLD2	P49005	POLD1	Homo sapiens	P28340	Pull Down	16510448
Intra	POLD2	P49005	POLD3	Homo sapiens	Q15054	Pull Down	31449058
Intra	POLD2	P49005	POLD3	Homo sapiens	Q15054	Pull Down	16510448
Intra	POLD2	P49005	POLD3	Homo sapiens	Q15054	Y2H	16000169
Intra	POLD2	P49005	POLD3	Homo sapiens	Q15054	Anti Tag CoIP	33961781
Intra	POLD2	P49005	POLD3	Homo sapiens	Q15054	Anti Tag CoIP	31449058
Intra	POLD2	P49005	POLD3	Homo sapiens	Q15054	Anti Tag CoIP	28514442
Intra	POLD2	P49005	POLD4	Homo sapiens	Q9HCU8	Anti Tag CoIP	33961781
Intra	POLD2	P49005	POLD4	Homo sapiens	Q9HCU8	Anti Tag CoIP	28514442
Intra	POLD2	P49005	POLD4	Homo sapiens	Q9HCU8	Y2H	16510448
Intra	POLD2	P49005	POLD4	Homo sapiens	Q9HCU8	Pull Down	16510448

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant POLD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71220	POLD2 Protein, Human (His)	P49005 (M1-P469)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Malignant Breast Melanoma	Malignant Melanoma Of Breast Breast Melanoma
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18543	Pold2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10820	POLD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25025	Pold2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	POLD2	VGNC	VGNC:76203
Bos taurus	POLD2	VGNC	VGNC:33114
Felis catus	POLD2	VGNC	VGNC:68937
Mus musculus	POLD2	MGD	MGI:1097163
Canis familiaris	POLD2	VGNC	VGNC:44775
Rattus norvegicus	POLD2	RGD	RGD:1304954
Others	POLD2	NCBI