POLD4 - DNA polymerase delta 4, accessory subunit Gene

Also Known as p12; POLDS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57804

About POLD4

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,350,765-67,353,596 (from NCBI)

This gene has 12 transcripts (splice variants) and 165 orthologues. Ubiquitous expression in lymph node (RPKM 33.7), small intestine (RPKM 29.8) and 25 other tissues.

Summary

This gene encodes the smallest subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA Polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

POLD4 Products (2)

mRNA Protein Name
NM_001256870.2 NP_001243799.1 DNA polymerase delta subunit 4 isoform 2
NM_021173.5 NP_066996.3 DNA polymerase delta subunit 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12403614 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA-templated DNA replication IDA
IDA: Inferred from direct assay
20334433 GOA
Cellular Component GO Annotation Evidence References Source
part of delta DNA polymerase complex IPI
IPI: Inferred from physical interaction
12403614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLD4 Protein Structure

DNA_pol_delta_4

DNA_pol_delta_4: DNA polymerase delta, subunit 4 (1 - 103)

  • 0
  • 100
  • 107 a.a.
Protein Preferred Names Protein Names

DNA polymerase delta subunit 4

  • DNA polymerase delta smallest subunit p12

POLD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POLD4 Q9HCU8 PCNA Homo sapiens P12004
ELISA
16510448
Intra
POLD4 Q9HCU8 POLD2 Homo sapiens P49005
Pull Down
16510448
Intra
POLD4 Q9HCU8 POLD2 Homo sapiens P49005
Pull Down
31449058
Intra
POLD4 Q9HCU8 POLD1 Homo sapiens P28340
Y2H
16510448
Intra
POLD4 Q9HCU8 POLD1 Homo sapiens P28340
Pull Down
31449058
Intra
POLD4 Q9HCU8 POLD1 Homo sapiens P28340
Pull Down
16510448
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10822 POLD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus POLD4 VGNC VGNC:105828
Rattus norvegicus POLD4 RGD RGD:1308519
Macaca mulatta POLD4 VGNC VGNC:101382
Mus musculus POLD4 MGD MGI:1916995
Others POLD4 NCBI