2. Gene
  3. POLD4 - DNA polymerase delta 4, accessory subunit Gene

POLD4 - DNA polymerase delta 4, accessory subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as p12; POLDS

Gene ID: 57804 | Gene type: protein coding

About POLD4

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,350,765-67,353,596 (from NCBI)

This gene has 12 transcripts (splice variants) and 165 orthologues. Ubiquitous expression in lymph node (RPKM 33.7), small intestine (RPKM 29.8) and 25 other tissues.

Summary

This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

POLD4 Products(2)

mRNA Protein Name
NM_001256870.2 NP_001243799.1 DNA polymerase delta subunit 4 isoform 2
NM_021173.5 NP_066996.3 DNA polymerase delta subunit 4 isoform 1

POLD4 Protein Structure

DNA_pol_delta_4

DNA_pol_delta_4: DNA polymerase delta, subunit 4 (1 - 103)

  • 0
  • 100
  • 107 a.a.
Protein Preferred Names Protein Names

DNA polymerase delta subunit 4

DNA polymerase delta smallest subunit p12

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10822 POLD4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus POLD4 VGNC VGNC:105828
Rattus norvegicus POLD4 RGD RGD:1308519
Macaca mulatta POLD4 VGNC VGNC:101382
Mus musculus POLD4 MGD MGI:1916995