CAPN9 - calpain 9 Gene

Also Known as GC36; nCL-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10753

About CAPN9

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:230,747,388-230,801,989 (from NCBI)

This gene has 4 transcripts (splice variants), 209 orthologues and 20 paralogues. Biased expression in stomach (RPKM 15.1), colon (RPKM 3.9) and 3 other tissues.

Summary

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric Cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CAPN9 Products (3)

mRNA Protein Name
NM_001319676.2 NP_001306605.1 calpain-9 isoform 3
NM_006615.3 NP_006606.1 calpain-9 isoform 1
NM_016452.3 NP_057536.1 calpain-9 isoform 2

CAPN9 Protein Structure

Peptidase_C2

Peptidase_C2: Calpain family cysteine protease (42 - 337)

Calpain_III

Calpain_III: Calpain large subunit, domain III (348 - 491)

EF-hand_6

EF-hand_6: EF-hand domain (597 - 622)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
Protein Preferred Names Protein Names

calpain-9

  • digestive tract-specific calpain

Related Diseases

Diseases Alias
Noonan Syndrome 4

  • NS4

  • Noonan Syndrome, Type 4
D-Glyceric Aciduria

  • D-Glyceric Acidemia

  • D-Glycericacidemia

  • Glycerate Kinase Deficiency

  • D-Glycerate Kinase Deficiency

  • Non Ketotic Hyperglycinemia Syndrome

  • Deficiency Of Glycerate Kinase

  • Hyperglycinemia, Non-Ketotic

  • D-GA
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Inflammatory Bowel Disease 15

  • IBD15
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01894 CAPN9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22413 Capn9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CAPN9 RGD RGD:70965
Mus musculus CAPN9 MGD MGI:1920897
Macaca mulatta CAPN9 VGNC VGNC:70537
Felis catus CAPN9 VGNC VGNC:60358
Canis familiaris CAPN9 VGNC VGNC:38708
Others CAPN9 NCBI