CAPN9 - calpain 9 Gene

Homo sapiens

Also known as GC36; nCL-4

Gene ID: 10753 | Gene type: protein coding

About CAPN9

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:230,747,388-230,801,989 (from NCBI)

This gene has 4 transcripts (splice variants), 209 orthologues and 20 paralogues. Biased expression in stomach (RPKM 15.1), colon (RPKM 3.9) and 3 other tissues.

Summary

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric Cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CAPN9 Products(3)

mRNA	Protein	Name
NM_001319676.2	NP_001306605.1	calpain-9 isoform 3
NM_006615.3	NP_006606.1	calpain-9 isoform 1
NM_016452.3	NP_057536.1	calpain-9 isoform 2

CAPN9 Protein Structure

Peptidase_C2

Calpain_III

EF-hand_6

0
200
400
600
690 a.a.

Protein Preferred Names

Protein Names

calpain-9

digestive tract-specific calpain

Related Diseases

Diseases

Alias

Noonan Syndrome 4

NS4	Noonan Syndrome, Type 4

D-Glyceric Aciduria

D-Glyceric Acidemia	D-Glycericacidemia
Glycerate Kinase Deficiency	D-Glycerate Kinase Deficiency
Non Ketotic Hyperglycinemia Syndrome	Deficiency Of Glycerate Kinase
Hyperglycinemia, Non-Ketotic	D-GA

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Inflammatory Bowel Disease 15

IBD15

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01894	CAPN9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CAPN9	RGD	RGD:70965
Mus musculus	CAPN9	MGD	MGI:1920897
Macaca mulatta	CAPN9	VGNC	VGNC:70537
Felis catus	CAPN9	VGNC	VGNC:60358
Canis familiaris	CAPN9	VGNC	VGNC:38708

Name
Email *

	Sorry, but the email address you supplied was invalid.