Jmjd6 - jumonji domain containing 6 Gene

Also Known as PSR; Ptdsr; PtdSerR; mKIAA0585; D11Ertd195e; 5730436I23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107817

Summary

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein functions in differentiation of multiple tissues during development, and in anti-inflammatory cytokine signaling. It was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that this protein does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. [provided by RefSeq, Jul 2008]

Jmjd6 Products (2)

mRNA Protein Name
NM_001363363.1 NP_001350292.1 bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 1
NM_033398.3 NP_203971.2 bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
21060799 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
21060799 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21300889 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
10811223 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
14715629 MGI
NOT acts upstream of or within apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
15345036 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
14715629 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
15615595 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
10811223 MGI
acts upstream of or within erythrocyte development IMP
IMP: Inferred from mutant phenotype
14715629 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15615595 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
15345036 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
14645847 MGI
acts upstream of or within macrophage activation IMP
IMP: Inferred from mutant phenotype
15345036 MGI
involved in negative regulation of protein homooligomerization IDA
IDA: Inferred from direct assay
33443146 MGI
involved in non-membrane-bounded organelle assembly IDA
IDA: Inferred from direct assay
33443146 MGI
acts upstream of or within recognition of apoptotic cell IDA
IDA: Inferred from direct assay
10811223 MGI
acts upstream of or within recognition of apoptotic cell IMP
IMP: Inferred from mutant phenotype
14645847 MGI
involved in regulation of mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
21300889 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
15345036 MGI
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
21300889 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21060799 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
21060799 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
21060799 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
33443146 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14729065 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10811223 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
21060799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

  • apoptotic cell clearance receptor PtdSerR

  • histone arginine demethylase JMJD6

  • jmjC domain-containing protein 6

  • jumonji domain-containing protein 6

  • lysyl-hydroxylase JMJD6

  • peptide-lysine 5-dioxygenase JMJD6

  • phosphatidylserine receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139782 SKLB325 99.21% Unkown
HY-139434 JMJD6-IN-1 Inhibitor 99.51% Unkown
HY-P10446 TAT-PiET-PROTAC Inhibitor 98.04% Unkown
HY-P10445 TAT-PiET Inhibitor / Unkown
HY-RS07039 JMJD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17009 Jmjd6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23452 Jmjd6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jmjd6 NCBI NCBI:23210