CCR9 - C-C motif chemokine receptor 9 Gene

Homo sapiens

Also known as GPR28; CDw199; GPR-9-6; CC-CKR-9

Gene ID: 10803 | Gene type: protein coding

About CCR9

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,886,064-45,903,174 (from NCBI)

This gene has 4 transcripts (splice variants), 265 orthologues and 23 paralogues. Biased expression in small intestine (RPKM 2.0), duodenum (RPKM 1.6) and 6 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta Chemokine Receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, Apoptosis, invasion, migration and drug resistance. This gene maps to the Chemokine Receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

CCR9 Products(5)

mRNA	Protein	Name
NM_001386447.1	NP_001373376.1	C-C chemokine receptor type 9 isoform A
NM_006641.4	NP_006632.2	C-C chemokine receptor type 9 isoform B
NM_031200.3	NP_112477.1	C-C chemokine receptor type 9 isoform A
NM_001256369.2	NP_001243298.1	C-C chemokine receptor type 9 isoform B
NM_001386448.1	NP_001373377.1	C-C chemokine receptor type 9 isoform A

CCR9 Protein Structure

7tm_1

0
100
200
300
369 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 9

G protein-coupled receptor 28

chemokine (C-C motif) receptor 9

Recombinant CCR9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700544	CCR9 Protein, Human (GST)	P51686 (M1-S48)	≥95%

Related Diseases

Diseases

Alias

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Ascending Cholangitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Ileitis

Crohn'S Ileitis

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Immunodeficiency 49

IMD49	Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities	Immunodeficiency 49, Severe Combined
Scid, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities	Severe Combined Immunodeficiency, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities
Scid, T-Cell-Negative, B-Cell-Positive, Nk-Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15724	Vercirnon	Antagonist	98.26%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15724A	Vercirnon sodium	Antagonist	99.13%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCR9	MGD	MGI:1341902
Macaca mulatta	CCR9	VGNC	VGNC:70742
Felis catus	CCR9	VGNC	VGNC:102024
Bos taurus	CCR9	VGNC	VGNC:26989
Canis familiaris	CCR9	VGNC	VGNC:38917
Rattus norvegicus	CCR9	RGD	RGD:628750
Others	CCR9	NCBI

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