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Grm5 - glutamate receptor, metabotropic 5 Gene

Also Known as Glu5R; Gprc1e; mGluR5; mGluR5b; 6430542K11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 108071

About Grm5

Chromosome 7: 87,233,376-87,784,115 forward strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 270 orthologues, 7 paralogues and is associated with 23 phenotypes. Biased expression in CNS E18 (RPKM 1.5), frontal lobe adult (RPKM 8.7) and 4 other tissues.

Summary

Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and modulation of age-related behavioral decline. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including Schaffer collateral - CA1 synapse; neuron projection; and plasma membrane. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Grm5 Products (2)

mRNA	Protein	Name
NM_001143834.1	NP_001137306.1	metabotropic glutamate receptor 5 isoform b precursor
NM_001081414.2	NP_001074883.1	metabotropic glutamate receptor 5 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12176012	MGI
enables protein tyrosine kinase activator activity	IGI IGI: Inferred from genetic interaction	24012003	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	24012003	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	9185557	MGI
involved in learning or memory	IGI IGI: Inferred from genetic interaction	24012003	MGI
acts upstream of or within locomotory behavior	IGI IGI: Inferred from genetic interaction	16280580	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	16280580	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	11431513	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	11431513	MGI
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	24012003	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	16024054	MGI
involved in synapse organization	IGI IGI: Inferred from genetic interaction	24012003	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11431513	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	11431513	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12176012	MGI
is active in dendrite	IDA IDA: Inferred from direct assay	24012003	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	21795692	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12176012	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm5 Protein Structure

PBP1_mGluR_groupI

NCD3G

7tmC_mGluR5

DUF5585

GluR_Homer-bdg

0
200
400
600
800
1000
1203 a.a.

Protein Preferred Names	Protein Names
metabotropic glutamate receptor 5	G protein-coupled receptor GRM5 G protein-coupled receptor, family C, group 1, member E metabotropic glutamate receptor subtype 5b metabotropic glutamate receptor type 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05831	GRM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05832	Grm5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05833	Grm5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm5	NCBI	NCBI:2915