CGB3 - chorionic gonadotropin subunit beta 3 Gene

Also Known as CGB; LHB; CGB5; CGB7; CGB8; hCGB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1082

About CGB3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,022,869-49,024,333 (from NCBI)

This gene has 1 transcript (splice variant), 33 orthologues and 9 paralogues. Restricted expression toward placenta (RPKM 30.5).

Summary

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein Hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the Steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

CGB3 Products (1)

mRNA Protein Name
NM_000737.5 NP_000728.1 choriogonadotropin subunit beta 3 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7922031 GOA
Cellular Component GO Annotation Evidence References Source
part of pituitary gonadotropin complex IPI
IPI: Inferred from physical interaction
7922031 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

choriogonadotropin subunit beta 3

  • CG-beta

CGB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CGB5 P0DN86 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Intra
CGB5 P0DN86 SMCP Homo sapiens P49901
Validated Y2H
32296183
Intra
CGB5 P0DN86 SMCP Homo sapiens P49901
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CGB3 Proteins

Cat. No. Product Name Accession Purity
HY-P7870 CGA-CGB3 Heterodimer Protein, Human (HEK293, His) P01215 (A25-S116)&P0DN86 (S21-Q165) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P7893 CG beta 3 Protein, Human (HEK293, His) P0DN86 (S21-Q165) ≥ 95%, as determined by reducing SDS-PAGE.

CGB3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86051 hCG beta Antibody (YA5743) IHC-P, ICC/IF, ELISA Human
HY-P87160 hCG beta Antibody (YA6853) IHC-P Human

Related Diseases

Diseases Alias
Ectopic Pregnancy

  • Eccyesis

  • Pregnancy Ectopic

  • Pregnancy, Ectopic

  • Ectopic Pregnancies

  • Extrauterine Gestation Or Pregnancy

  • Extrauterine Pregnancy

  • Ep - [Ectopic Pregnancy]

  • Ectopic Mole

  • Aborted Ectopic Pregnancy

  • Ruptured Ectopic Pregnancy
Endodermal Sinus Tumor

  • Yolk Sac Tumor

  • Endodermal Sinus Tumour

  • Hepatoid Yolk Sac Tumour

  • Infantile Embryonal Carcinoma

  • Yolk Sac Neoplasm

  • Yolk Sac Tumour
Germinoma
Seminoma

  • Seminoma, Pure
Teratoma

  • Teratomas
Choriocarcinoma

  • Chorioepithelioma
Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole

  • Gestational Trophoblastic Disease

  • Complete Hydatidiform Mole

  • Hydm

  • HYDM1

  • Chm

  • Molar Pregnancy

  • Hydatidiform Mole, Complete

  • Hydatid Mole

  • Complete Molar Pregnancy

  • Mole, Hydatidiform, Recurrent, Type 1

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 2

  • Classical Hydatidiform Mole
Placental Site Trophoblastic Tumor

  • Trophoblastic Tumor Placental Site

  • Trophoblastic Tumor, Placental Site

  • Placental Site Trophoblastic Tumour

  • Placental-Site Gestational Trophoblastic Neoplasm

  • Placenta Neoplasm

  • Psst

  • Deciduoma

  • Placental Cancer

  • Primary Malignant Neoplasm Of Placenta
Gestational Trophoblastic Neoplasm

  • Hydatidiform Mole

  • Molar Pregnancy

  • Gestational Trophoblastic Neoplasia

  • Gestational Trophoblastic Tumor

  • Gtn

  • Gestational Trophoblastic Disease

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole Benign

  • Trophoblastic Disease

  • Trophoblastic Disease Nos

  • Trophoblastic Disorder

  • Vesicular Mole Nos

  • Vesicular Mole

  • Hydatidiform Mole Nos
Placenta Disease

  • Placenta Diseases

  • Placenta Disorder

  • Pregnancy Complications

  • Placenta Disorders
Turner Syndrome

  • Monosomy X

  • Gonadal Dysgenesis Turner Type

  • Ullrich-Turner Syndrome

  • Bonnevie-Ullrich Syndrome

  • Karyotype 45, X

  • Genital Dwarfism, Turner Type

  • Gonadal Dysgenesis

  • 45,X

  • Turner'S Syndrome

  • Gonadal Dysgenesis - Turner

  • Monosomy X Syndrome

  • Xo Syndrome

  • Genital Dwarfism

  • 45, X Syndrome

  • Bonnevie-Ulrich Syndrome

  • Chromosome X Monosomy X

  • Schereshevkii Turner Syndrome

  • Turner Varny Syndrome

  • Ts

  • 45,X Syndrome

  • 45,X/46,Xx Syndrome

  • Turners Syndrome

  • Gonadal Dysgenesis, 45,X

  • X0 Syndrome
Chromosomal Triplication

  • Trisomy
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Embryonal Carcinoma

  • Embryonal Neoplasm

  • Embryonal Cancer

  • Primary Extragonadal Embryonal Carcinoma

  • Embryo Neoplasm

  • Carcinoma Embryonal

  • Cancer Embryonal

  • Carcinoma, Embryonal

  • Extragonadal Embryonal Carcinoma

  • Cancer, Embryonal
Placenta Accreta
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Tricuspid Valve Insufficiency

  • Tricuspid Regurgitation

  • Tricuspid Valve Regurgitation

  • Tricuspid Incompetence

  • Tr - [Tricuspid Regurgitation]

  • Tricuspid Valve Incompetency

  • Tricuspid Valve Annular Incompetency
Gonadoblastoma

  • GBY
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Mixed Ductal-Endocrine Carcinoma
Pulmonary Blastoma

  • Blastoma Of Lung

  • Pneumoblastoma
Sertoli Cell Tumor

  • Tubular Androblastoma
Transitional Cell Carcinoma

  • Transitional Cell Neoplasm

  • Carcinoma, Transitional Cell

  • Transitional Carcinoma

  • Transitional Cell Tumor

  • Urothelial Cell Carcinoma

  • Carcinoma Transitional Cell

  • Transitional Cell Carcinoma Of Bladder
Leydig Cell Hypoplasia Type Ii

  • 46,Xy Disorder Of Sex Developement Due To Partial Lh Receptor Inactivation

  • 46,Xy Disorder Of Sex Developement Due To Partial Lh Resistance

  • 46,Xy Disorder Of Sex Developement Due To Partial Luteinizing Hormone Resistance

  • 46,Xy Dsd Due To Partial Lh Receptor Inactivation

  • 46,Xy Dsd Due To Partial Lh Resistance

  • 46,Xy Dsd Due To Partial Luteinizing Hormone Resistance

  • Leydig Cell Hypoplasia Due To Partial Lh Receptor Inactivation

  • Leydig Cell Hypoplasia Due To Partial Lh Resistance

  • Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Receptor Inactivation

  • Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Resistance

  • Leydig Cell Hypoplasia, Type Ii
Placental Abruption

  • Abruptio Placentae

  • Abruptio Placenta

  • Abortion, Threatened

  • Threatened Miscarriage

  • Haemorrhage Specified As Due To Threatened Abortion

  • Spontaneous Threatened Abortion
Gonadal Dysgenesis

  • Gonadal Dysgenesis Syndrome

  • Turner Syndrome
Patellofemoral Pain Syndrome
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Infertility
Epidermoid Cysts

  • Epidermoid Cyst

  • Sebaceous Cyst

  • Epidermal Inclusion Cyst

  • Epidermal Cyst
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Serotonin Syndrome

  • Serotonergic Syndrome

  • Serotonin Storm

  • Serotonin Toxicity

  • Serotonin Toxidrome

  • Malignant Carcinoid Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02581 CGB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CGB3 MGD MGI:96782