E2f8 - E2F transcription factor 8 Gene

Also Known as 4432406C08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108961

Summary

Enables DNA binding activity; DNA-binding transcription repressor activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; regulation of cell cycle process; and trophoblast giant cell differentiation. Acts upstream of or within cell population proliferation. Located in nucleus. Is expressed in central nervous system and retina. Orthologous to human E2F8 (E2F transcription factor 8). [provided by Alliance of Genome Resources, Apr 2022]

E2f8 Products (2)

mRNA Protein Name
NM_001013368.5 NP_001013386.2 transcription factor E2F8
NM_001360812.1 NP_001347741.1 transcription factor E2F8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15722552 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
22516201 MGI
enables DNA-binding transcription repressor activity IMP
IMP: Inferred from mutant phenotype
22516201 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
15722552 MGI
Biological Process GO Annotation Evidence References Source
involved in cell cycle comprising mitosis without cytokinesis IMP
IMP: Inferred from mutant phenotype
23064266 MGI
involved in chorionic trophoblast cell differentiation IMP
IMP: Inferred from mutant phenotype
22516201 MGI
acts upstream of or within fibroblast proliferation IDA
IDA: Inferred from direct assay
15722552 MGI
involved in hepatocyte differentiation IMP
IMP: Inferred from mutant phenotype
23064264 MGI
involved in negative regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
23064264 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22516201 MGI
involved in placenta development IMP
IMP: Inferred from mutant phenotype
22516201 MGI
involved in positive regulation of DNA endoreduplication IMP
IMP: Inferred from mutant phenotype
23064264 MGI
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
22903062 MGI
involved in trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
23064266 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15722552 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor E2F8

  • E2f family member 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04117 E2F8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22149 E2f8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens E2f8 NCBI NCBI:79733