Acat1 - acetyl-Coenzyme A acetyltransferase 1 Gene

Also Known as Acat; 6330585C21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110446

About Acat1

Chromosome 9: 53,491,822-53,521,682 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 202 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in liver E18 (RPKM 193.6), heart adult (RPKM 69.) and 2 other tissues.

Summary

Enables acetyl-CoA C-acetyltransferase activity. Predicted to be involved in carboxylic acid catabolic process; ketone body catabolic process; and purine nucleoside bisphosphate metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in brain; embryo; heart; liver; and metanephros. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Acat1 Products (1)

mRNA Protein Name
NM_144784.3 NP_659033.1 acetyl-CoA acetyltransferase, mitochondrial precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables acetyl-CoA C-acetyltransferase activity IDA
IDA: Inferred from direct assay
7592824 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acat1 Protein Structure

thiolase

thiolase: cd00751 (39 - 422)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
Protein Preferred Names Protein Names

acetyl-CoA acetyltransferase, mitochondrial

  • acetoacetyl-CoA thiolase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-13215 Avasimibe Inhibitor 99.85% Phase 3
HY-100401 Pactimibe Inhibitor 99.98% Phase 3
HY-100400A K-604 dihydrochloride Inhibitor 99.42% Phase 2
HY-100399A Nevanimibe hydrochloride Inhibitor 99.49% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100399 Nevanimibe Inhibitor 98.99% Yes
HY-100401A Pactimibe sulfate Inhibitor 98.0% Unkown
HY-N18066 Esculeogenin A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acat1 NCBI NCBI:38