UBE2C - ubiquitin conjugating enzyme E2 C Gene

Homo sapiens

Also known as UBCH10; dJ447F3.2

Gene ID: 11065 | Gene type: protein coding

About UBE2C

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,812,644-45,816,952 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues and 24 paralogues. Biased expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.0) and 13 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in Cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

UBE2C Products(6)

mRNA	Protein	Name
NM_001281741.2	NP_001268670.1	ubiquitin-conjugating enzyme E2 C isoform 6
NM_001281742.2	NP_001268671.1	ubiquitin-conjugating enzyme E2 C isoform 7
NM_007019.4	NP_008950.1	ubiquitin-conjugating enzyme E2 C isoform 1
NM_181799.3	NP_861515.1	ubiquitin-conjugating enzyme E2 C isoform 2
NM_181800.3	NP_861516.1	ubiquitin-conjugating enzyme E2 C isoform 3
NM_181801.4	NP_861517.1	ubiquitin-conjugating enzyme E2 C isoform 4

UBE2C Protein Structure

UQ_con

0
100
179 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 C

(E3-independent) E2 ubiquitin-conjugating enzyme C

Recombinant UBE2C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71016	UBE2C Protein, Human (His)	O00762 (M1-P179)	≥95%

Related Diseases

Diseases

Alias

Complement Component 7 Deficiency

C7 Deficiency

C7D

Methotrexate-Associated Lymphoproliferation

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147291	VPC-70063		/	Unkown
HY-RS15338	UBE2C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UBE2C	VGNC	VGNC:99692
Canis familiaris	UBE2C	VGNC	VGNC:48049
Bos taurus	UBE2C	VGNC	VGNC:36578
Mus musculus	UBE2C	MGD	MGI:1915862
Rattus norvegicus	UBE2C	RGD	RGD:1305382
Others	UBE2C	NCBI

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