UBE2C - ubiquitin conjugating enzyme E2 C Gene

Also Known as UBCH10; dJ447F3.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11065

About UBE2C

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,812,644-45,816,952 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues and 24 paralogues. Biased expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.0) and 13 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, ubiquitin-conjugating Enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in Cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

UBE2C Products (6)

mRNA Protein Name
NM_001281741.2 NP_001268670.1 ubiquitin-conjugating enzyme E2 C isoform 6
NM_001281742.2 NP_001268671.1 ubiquitin-conjugating enzyme E2 C isoform 7
NM_007019.4 NP_008950.1 ubiquitin-conjugating enzyme E2 C isoform 1
NM_181799.3 NP_861515.1 ubiquitin-conjugating enzyme E2 C isoform 2
NM_181800.3 NP_861516.1 ubiquitin-conjugating enzyme E2 C isoform 3
NM_181801.4 NP_861517.1 ubiquitin-conjugating enzyme E2 C isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19822757 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
12629039 GOA
enables ubiquitin-like protein ligase binding IPI
IPI: Inferred from physical interaction
15749827 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18485873 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20061386 GOA
Biological Process GO Annotation Evidence References Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
9122200 GOA
involved in exit from mitosis IMP
IMP: Inferred from mutant phenotype
19822757 GOA
involved in free ubiquitin chain polymerization IDA
IDA: Inferred from direct assay
19822757 GOA
involved in positive regulation of exit from mitosis IMP
IMP: Inferred from mutant phenotype
9122200 GOA
involved in positive regulation of mitotic metaphase/anaphase transition IDA
IDA: Inferred from direct assay
12629039 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
27910872 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
9122200 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
9122200 GOA
Cellular Component GO Annotation Evidence References Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
16413484 GOA
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
15749827 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2C Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (34 - 167)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 C

  • (E3-independent) E2 ubiquitin-conjugating enzyme C

UBE2C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2C O00762 MAPK7 Homo sapiens Q13164
Y2H Prey Pooling
32296183
Intra
UBE2C O00762 MAPK7 Homo sapiens Q13164
Validated Y2H
32296183
Intra
UBE2C O00762 MAPK7 Homo sapiens Q13164
Y2H Array
32296183
Intra
UBE2C O00762 GNB2 Homo sapiens P62879
Y2H Pooling
32814053
Intra
UBE2C O00762 GNB2 Homo sapiens P62879
Validated Y2H
32814053
Intra
UBE2C O00762 GNB2 Homo sapiens P62879
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

UBE2C Antibodies

Cat. No. Product Name Application Reactivity
HY-P82989 Ubiquitin Conjugating Enzyme E2 C Antibody (YA2734) WB Human

Related Diseases

Diseases Alias
Complement Component 7 Deficiency

  • C7 Deficiency

  • C7D
Methotrexate-Associated Lymphoproliferation
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147291 VPC-70063 99.92% Unkown
HY-RS15338 UBE2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16829 Ube2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183287 Androgen receptor antagonist-14 Antagonist / Unkown
HY-P10800 T20-M / Unkown
HY-RS23271 Ube2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus UBE2C VGNC VGNC:99692
Canis familiaris UBE2C VGNC VGNC:48049
Bos taurus UBE2C VGNC VGNC:36578
Mus musculus UBE2C MGD MGI:1915862
Rattus norvegicus UBE2C RGD RGD:1305382
Others UBE2C NCBI