Cpb2 - carboxypeptidase B2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 113936

Summary

Enables Carboxypeptidase activity. Involved in several processes, including liver regeneration; negative regulation of hepatocyte proliferation; and regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPB2 (Carboxypeptidase B2). [provided by Alliance of Genome Resources, Apr 2022]

Cpb2 Products (1)

mRNA Protein Name
NM_053617.2 NP_446069.1 carboxypeptidase B2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carboxypeptidase activity IDA
IDA: Inferred from direct assay
11021404 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
23369837 RGD
involved in fibrinolysis IMP
IMP: Inferred from mutant phenotype
11848438 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
19386599 RGD
involved in negative regulation of fibrinolysis IDA
IDA: Inferred from direct assay
17002650 RGD
involved in negative regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
19386599 RGD
involved in negative regulation of plasminogen activation IMP
IMP: Inferred from mutant phenotype
23369837 RGD
involved in positive regulation of extracellular matrix constituent secretion IMP
IMP: Inferred from mutant phenotype
23369837 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
11021404 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17911187 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
17911187 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carboxypeptidase B2

  • CPR

  • CPU

  • TAFI

  • carboxypeptidase B2 (plasma)

  • carboxypeptidase R

  • carboxypeptidase U

  • thrombin-activable fibrinolysis inhibitor

Recombinant Cpb2 Proteins

Cat. No. Product Name Accession Purity
HY-P75449 Carboxypeptidase B2/CPB2 Protein, Rat (HEK293, His) Q9EQV9 (F22-S422) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163617 c-PB2(OH)2 Inhibitor / Unkown
HY-RS03088 CPB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17450 Cpb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23906 Cpb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpb2 NCBI NCBI:1361
Mus musculus Cpb2 NCBI NCBI:56373