C5ar1 - complement C5a receptor 1 Gene

Also Known as C5aR; C5r1; C5a-R

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 113959

Summary

Enables complement component C5a binding activity and complement component C5a receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of neuron apoptotic process; and response to lipopolysaccharide. Located in cell surface and plasma membrane. Used to study adult respiratory distress syndrome; amyotrophic lateral sclerosis; neutropenia; obesity; and thrombosis. Biomarker of asthma and lung disease. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

C5ar1 Products (1)

mRNA Protein Name
NM_053619.2 NP_446071.1 C5a anaphylatoxin chemotactic receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables complement component C5a binding IDA
IDA: Inferred from direct assay
15292245 RGD
enables complement component C5a receptor activity IDA
IDA: Inferred from direct assay
9464523 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
15322206 RGD
involved in cell proliferation in hindbrain IMP
IMP: Inferred from mutant phenotype
18635264 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
15292245 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15292245 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
9272704 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
15322206 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
9464523 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C5a anaphylatoxin chemotactic receptor 1

  • complement component 5, receptor 1

  • complement component 5a receptor 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106178 PMX-53 Antagonist 99.95% Phase 2
HY-157472 ACT-1014-6470 Antagonist / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99450 Avdoralimab Inhibitor 99.25% Phase 2
HY-P990745 Izastobart Ligand 99% Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110136A PMX 205 Trifluoroacetate Antagonist 99.50% Unkown
HY-148141 JPE-1375 Antagonist 99.96% Unkown
HY-145237 BM213 99.62% Unkown
HY-P10639 C5aR2 agonist P32 Agonist 99.17% Unkown
HY-W157299 2-(Bromomethyl)-1-fluoro-3-methoxybenzene / Unkown
HY-163378 C5aR1 antagonist 1 Antagonist / Unkown
HY-163379 C5aR1 antagonist 2 Antagonist / Unkown
HY-175981 Paclitaxel-bromothiophene / Unkown
HY-RS01750 C5AR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10639A C5aR2 agonist P32 acetate Agonist / Unkown
HY-RS18377 C5ar1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24857 C5ar1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W130878 4-Octylphenol Activator / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991485 Anti-CD88/C5AR1 Antibody (G2_anti-C5aR) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens C5ar1 NCBI NCBI:728