Vegfc - vascular endothelial growth factor C Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114111

Summary

Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including positive regulation of blood vessel endothelial cell migration; positive regulation of protein autophosphorylation; and regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within positive regulation of neuroblast proliferation. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of colon adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C). [provided by Alliance of Genome Resources, Apr 2022]

Vegfc Products (1)

mRNA Protein Name
NM_053653.2 NP_446105.1 vascular endothelial growth factor C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables vascular endothelial growth factor receptor 3 binding IMP
IMP: Inferred from mutant phenotype
11683876 RGD
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
12706123 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
19412173 RGD
involved in positive regulation of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
12706123 RGD
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16462734 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16618418 RGD
acts upstream of or within positive regulation of neuroblast proliferation IDA
IDA: Inferred from direct assay
16462734 RGD
involved in positive regulation of protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
11683876 RGD
involved in positive regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
16618418 RGD
involved in regulation of vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11683876 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19147132 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vascular endothelial growth factor C

  • VEGF-C

  • VRP

  • flt4 ligand

  • flt4-L

  • vascular endothelial growth factor-related protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P3369 Gersizangitide 97.16% Phase 2
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99830 Conbercept Inhibitor 98.42% Phase 4
HY-P990675 VGX-100 Inhibitor 99.54% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2187 Deoxyshikonin 99.96% Unkown
HY-P11474 FZ1 peptide 99.92% Unkown
HY-RS15637 VEGFC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174507 Human VEGFD mRNA / Unkown
HY-174508 Human VEGFC mRNA / Unkown
HY-RS16674 Vegfc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23109 Vegfc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9920A Ramucirumab (anti-VEGFR) Antagonist 99.9% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vegfc NCBI NCBI:7424