Hcn3 - hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114245

Summary

Predicted to enable voltage-gated Potassium Channel activity and voltage-gated Sodium Channel activity. Involved in cellular response to dopamine and response to cisplatin. Located in several cellular components, including cone cell pedicle; dendrite; and neuronal cell body. Biomarker of Parkinson's disease. Orthologous to human HCN3 (hyperpolarization activated cyclic nucleotide gated Potassium Channel 3). [provided by Alliance of Genome Resources, Apr 2022]

Hcn3 Products (1)

mRNA Protein Name
NM_053685.2 NP_446137.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to dopamine IEP
IEP: Inferred from expression pattern
19320057 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
14991560 RGD
located in cone cell pedicle IDA
IDA: Inferred from direct assay
12786975 RGD
located in dendrite IDA
IDA: Inferred from direct assay
14991560 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
14991560 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18940 Cilobradine / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160505 RO-275 Inhibitor 99.95% Unkown
HY-13422A Zatebradine Antagonist 99.27% Unkown
HY-13422 Zatebradine hydrochloride Antagonist 99.87% Unkown
HY-RS06048 HCN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19140 Hcn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20286 Hcn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25631 Hcn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcn3 NCBI NCBI:57657