Nppc - natriuretic peptide C Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114593

Summary

Enables hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and positive regulation of osteoblast differentiation. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C). [provided by Alliance of Genome Resources, Apr 2022]

Nppc Products (1)

mRNA Protein Name
NM_053750.1 NP_446202.1 C-type natriuretic peptide precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
12746286 RGD
Biological Process GO Annotation Evidence References Source
involved in cGMP-mediated signaling IDA
IDA: Inferred from direct assay
14691198 RGD
involved in negative regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
12746286 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17562543 RGD
involved in negative regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
12746286 RGD
involved in positive regulation of cGMP-mediated signaling IDA
IDA: Inferred from direct assay
12746286 RGD
involved in positive regulation of mast cell degranulation IDA
IDA: Inferred from direct assay
9663691 RGD
involved in positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
17562543 RGD
involved in positive regulation of uterine smooth muscle relaxation IDA
IDA: Inferred from direct assay
9663691 RGD
acts upstream of or within receptor guanylyl cyclase signaling pathway IDA
IDA: Inferred from direct assay
17951249 RGD
involved in regulation of smooth muscle cell proliferation IEP
IEP: Inferred from expression pattern
11742834 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
9042593 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16677483 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11476746 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16677483 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
19666697 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-type natriuretic peptide

  • natriuretic peptide precursor C

  • natriuretic peptide precursor type C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09496 NPPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20311 Nppc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26819 Nppc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nppc NCBI NCBI:4880