CYGB - cytoglobin Gene

Also Known as HGB; STAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114757

About CYGB

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,527,356-76,551,193 (from NCBI)

This gene has 5 transcripts (splice variants), 287 orthologues and 11 paralogues. Ubiquitous expression in fat (RPKM 16.5), urinary bladder (RPKM 7.0) and 23 other tissues.

Summary

This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate Hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

CYGB Products (1)

mRNA	Protein	Name
NM_134268.5	NP_599030.1	cytoglobin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carbon monoxide binding	IDA IDA: Inferred from direct assay	11893755	GOA
enables nitric oxide dioxygenase activity, heme protein as donor	IDA IDA: Inferred from direct assay	20511233	GOA
enables nitrite reductase activity	IDA IDA: Inferred from direct assay	29128400	GOA
enables oxygen binding	IDA IDA: Inferred from direct assay	11893755	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables superoxide dismutase activity	IDA IDA: Inferred from direct assay	34930834	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nitric oxide catabolic process	IDA IDA: Inferred from direct assay	28671819	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	34930834	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34930834	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	14660570	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14660570	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYGB Protein Structure

Globin

0
100
190 a.a.

Protein Preferred Names	Protein Names
cytoglobin	histoglobin

CYGB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CYGB	Q8WWM9	LRATD1	Homo sapiens	Q96KN4	Validated Y2H	32296183
Intra	CYGB	Q8WWM9	LRATD1	Homo sapiens	Q96KN4	Y2H Array	32296183
Intra	CYGB	Q8WWM9	LRATD1	Homo sapiens	Q96KN4	Y2H Prey Pooling	32296183
Intra	CYGB	Q8WWM9	PRR5-ARHGAP8	Homo sapiens	B1AHC3	Y2H Array	32296183
Intra	CYGB	Q8WWM9	PRR5-ARHGAP8	Homo sapiens	B1AHC3	Y2H Prey Pooling	32296183
Intra	CYGB	Q8WWM9	MZT1	Homo sapiens	Q08AG7	Y2H Prey Pooling	32296183
Intra	CYGB	Q8WWM9	MZT1	Homo sapiens	Q08AG7	Y2H Array	32296183
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	25416956
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Validated Y2H	25416956
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	32296183
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Y2H Array	25416956
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Y2H Array	32296183
Intra	CYGB	Q8WWM9	AKR7A2	Homo sapiens	O43488	Anti Tag CoIP	28536627
Intra	CYGB	Q8WWM9	AKR7A2	Homo sapiens	O43488	Y2H	28536627
Intra	CYGB	Q8WWM9	ARHGAP8	Homo sapiens	P85298-4	Y2H Array	32296183
Intra	CYGB	Q8WWM9	ARHGAP8	Homo sapiens	P85298-4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CYGB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70089	Cytoglobin/Histoglobin Protein, Human (His)	Q8WWM9 (M1-P190)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 36	RP36 Retinitis Pigmentosa-36 Retinitis Pigmentosa, Type 36
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Esophageal Diverticulosis	Diverticulosis, Esophageal
Atrophic Vulva	Atrophy Of Vulva
Epidural Abscess	Abscess Epidural
Xanthogranulomatous Pyelonephritis	Pyelonephritis, Xanthogranulomatous
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Bladder Tuberculosis	Tuberculous Cystitis Tuberculosis Of Bladder
Epiglottis Cancer	Epiglottic Cancer Malignant Tumor Of Epiglottis
Acquired Polycythemia	Secondary Polycythemia Polycythemia, Secondary Secondary Erythrocytosis Polycythemia Secondary
Femoral Neuropathy	Femoral Nerve Dysfunction Femoral Nerve Lesions
Thalassemia Minor
Active Peptic Ulcer Disease	Gi Bleeding Active Peptic Ulcer Gastrointestinal Hemorrhage
Iron Deficiency Anemia	Iron-Deficiency Anemia Fe Deficiency Anaemia Ida - [Iron Deficiency Anemia] Fe - [Iron] Deficiency Anemia Nos
Acute Chest Syndrome	Acute Chest Syndrome In Sickle Cell Disease
Splenic Infarction	Splenic Infarct Splenic Infarcts Infarct Of The Spleen
Compartment Syndrome	Compartment Syndromes Compartmental Syndrome
Idiopathic Peripheral Autonomic Neuropathy
Leech Infestation	Hirudiniasis Leeches
Hemoglobinopathy	Hemoglobinopathies
Inflammatory Liposarcoma
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Breast Rhabdomyosarcoma	Rhabdomyosarcoma Of The Breast
Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency	Favism Favism, Susceptibility To Hemolytic Anemia, G6pd Deficient Class I Glucose-6-Phosphate Dehydrogenase Deficiency Class I G6pd Deficiency Severe Hemolytic Anemia Due To G6pd Deficiency Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency NSHA G6pd Deficient Hemolytic Anemia
Geotrichosis
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Lipoma Of Colon	Colonic Lipoma Colon Lipoma
Large Intestine Lipoma	Lipoma Of Large Intestine Colorectal Lipoma
Pancytopenia
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03432	CYGB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18031	Cygb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24505	Cygb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CYGB	VGNC	VGNC:71421
Mus musculus	CYGB	MGD	MGI:2149481
Felis catus	CYGB	VGNC	VGNC:61317
Canis familiaris	CYGB	VGNC	VGNC:49090
Rattus norvegicus	CYGB	RGD	RGD:69415
Bos taurus	CYGB	VGNC	VGNC:50268
Others	CYGB	NCBI