Pawr - PRKC, apoptosis, WT1, regulator Gene

Also Known as PAR4; Par-4; 2310001G03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 114774

Summary

Predicted to enable actin binding activity; enzyme binding activity; and leucine zipper domain binding activity. Involved in negative regulation of fibroblast proliferation; regulation of cellular response to stress; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of lymphocyte proliferation; and positive regulation of amyloid precursor protein biosynthetic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PAWR (pro-apoptotic WT1 regulator). [provided by Alliance of Genome Resources, Apr 2022]

Pawr Products (1)

mRNA	Protein	Name
NM_054056.2	NP_473397.1	PRKC apoptosis WT1 regulator protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12917339	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	12917339	MGI
acts upstream of or within interleukin-2 production	IMP IMP: Inferred from mutant phenotype	12970181	MGI
acts upstream of or within negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12970181	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	12970181	MGI
acts upstream of or within negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12970181	MGI
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	25472717	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25472717	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25472717	MGI
acts upstream of or within positive regulation of amyloid precursor protein biosynthetic process	IDA IDA: Inferred from direct assay	14627703	MGI
involved in positive regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	25472717	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25472717	MGI
involved in positive regulation of hydrogen peroxide-mediated programmed cell death	IMP IMP: Inferred from mutant phenotype	25472717	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	25472717	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14627703	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12917339	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
PRKC apoptosis WT1 regulator protein	prostate apoptosis response 4 protein

Pawr Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pawr	Q925B0	Dapk3	Mus musculus	O54784	Y2H	12917339
Intra	Pawr	Q925B0	Dapk3	Mus musculus	O54784	CoIP	12917339

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10087	PAWR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21400	Pawr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27919	Pawr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pawr	NCBI	NCBI:5074