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PAWR - pro-apoptotic WT1 regulator Gene

Also Known as PAR4; Par-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5074

About PAWR

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:79,584,879-79,690,964 (from NCBI)

This gene has 11 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in endometrium (RPKM 8.7), thyroid (RPKM 5.9) and 24 other tissues.

Summary

This gene encodes a tumor suppressor protein that selectively induces Apoptosis in Cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated Apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]

PAWR Products (3)

mRNA	Protein	Name
NM_001354732.2	NP_001341661.1	PRKC apoptosis WT1 regulator protein isoform 1
NM_001354733.2	NP_001341662.1	PRKC apoptosis WT1 regulator protein isoform 2
NM_002583.4	NP_002574.2	PRKC apoptosis WT1 regulator protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables enzyme binding	IDA IDA: Inferred from direct assay	15671026	GOA
enables leucine zipper domain binding	IPI IPI: Inferred from physical interaction	14627703	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11755531	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14627703	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14627703	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
PRKC apoptosis WT1 regulator protein	PRKC, apoptosis, WT1, regulator

PAWR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PAWR	Q96IZ0	SPSB4	Homo sapiens	Q96A44	ITC	20561531
Intra	PAWR	Q96IZ0	SPSB1	Homo sapiens	Q96BD6	X-Ray Diffraction	20561531
Intra	PAWR	Q96IZ0	VIM	Homo sapiens	P08670	Anti Bait CoIP	25218743
Intra	PAWR	Q96IZ0	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	19632185
Intra	PAWR	Q96IZ0	HSPA5	Homo sapiens	P11021	Anti Bait CoIP	19632185
Intra	PAWR	Q96IZ0	HSPA5	Homo sapiens	P11021	IF	19632185
Cross	PAWR	Q96IZ0	Spsb2	Mus musculus	O88838	Anti Bait CoIP	16369487
Cross	PAWR	Q96IZ0	Spsb2	Mus musculus	O88838	ITC	20561531
Cross	PAWR	Q96IZ0	Spsb2	Mus musculus	O88838	NMR	20561531
Cross	PAWR	Q96IZ0	Spsb1	Mus musculus	Q9D5L7	ITC	20561531
Cross	PAWR	Q96IZ0	Spsb4	Mus musculus	Q8R5B6	ITC	20561531

Cross: Cross-species interaction Intra: Intraspecies interaction

PAWR Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82858	PAR4 Antibody (YA2603)	WB	Human, Mouse, Rat
HY-P85314	PAR4 Antibody (YA5006)	WB, IHC-P, ELISA	Human
HY-P85314A	PAR4 Antibody (YA5006)(PBS only)	WB, IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Gapo Syndrome	GAPOS Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10087	PAWR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21400	Pawr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27919	Pawr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PAWR	RGD	RGD:69065
Bos taurus	PAWR	VGNC	VGNC:106857
Mus musculus	PAWR	MGD	MGI:2149961
Macaca mulatta	PAWR	VGNC	VGNC:75759
Others	PAWR	NCBI