Spsb2 - splA/ryanodine receptor domain and SOCS box containing 2 Gene

Also Known as C9; SSB2; Grcc9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14794

Summary

This gene encodes a member of the SSB family of proteins that contain a central SPRY (repeats in splA and ryanodine receptors) domain and a C-terminal SOCS (suppressor of cytokine signaling) box. The encoded protein is an adaptor protein in the E3 ubiquitin Ligase complex that ubiquitinates inducible nitric oxide synthase and targets it for proteasomal degradation. Mice lacking the encoded protein exhibit lower blood urea nitrogen levels and mild thrombocytopenia due to reduced platelet production. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Spsb2 Products (10)

mRNA Protein Name
NM_001306050.2 NP_001292979.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001306051.2 NP_001292980.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001306052.2 NP_001292981.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001306053.2 NP_001292982.1 SPRY domain-containing SOCS box protein 2 isoform 2
NM_001409886.1 NP_001396815.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001409887.1 NP_001396816.1 SPRY domain-containing SOCS box protein 2 isoform 1
NM_001409888.1 NP_001396817.1 SPRY domain-containing SOCS box protein 2 isoform 2
NM_001409889.1 NP_001396818.1 SPRY domain-containing SOCS box protein 2 isoform 2
NM_001409890.1 NP_001396819.1 SPRY domain-containing SOCS box protein 2 isoform 2
NM_013539.3 NP_038567.1 SPRY domain-containing SOCS box protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16369487 MGI
Biological Process GO Annotation Evidence References Source
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
20603330 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
20603330 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SPRY domain-containing SOCS box protein 2

  • gene-rich cluster protein C9

Spsb2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Spsb2 O88838 PAWR Homo sapiens Q96IZ0
NMR
20561531
Cross
Spsb2 O88838 PAWR Homo sapiens Q96IZ0
Anti Tag CoIP
16369487
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10383 SPSB2-iNOS inhibitory cyclic peptide-1 99.81% Unkown
HY-P10383A SPSB2-iNOS inhibitory cyclic peptide-1 TFA / Unkown
HY-P10384 SPSB2-iNOS inhibitory cyclic peptide-2 Inhibitor / Unkown
HY-P10384A SPSB2-iNOS inhibitory cyclic peptide-2 TFA / Unkown
HY-P10385 SPSB2-iNOS inhibitory cyclic peptide-3 / Unkown
HY-P10385A SPSB2-iNOS inhibitory cyclic peptide-3 TFA / Unkown
HY-RS13727 SPSB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spsb2 NCBI NCBI:84727